Summary
Cigarette smokers have a phthalate noncovalently bound to their serum orosomucoid. The phthalate, whose concentration is dependent on the number of cigarettes smoked, is tentatively identified as a metabolite of di-(2-ethylhexyl)-phthalate, a common plasticizer. The binding of the ligand is in concert with the membership of orosomucoid in the lipocalin family and its role as a transporter of basic drugs. Smoking may have an effect on drug pharmacokinetics that is difficult to predict.
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Treuheit, M., Halsall, H.B. The existence of a ligand bound to the serum orosomucoid of cigarette smokers. Chromatographia 31, 63–66 (1991). https://doi.org/10.1007/BF02290498
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DOI: https://doi.org/10.1007/BF02290498