Abstract
We have synthesized a series of novel 2-amino-6-(nitroimidazolyl)thiopurines by reaction of thioguanine with 1-alkyl(1,2-dialkyl)-5-chloro-4-nitro-, 2-alkyl(1,2-dialkyl)-5-bromo-4-nitro-, and 1-alkyl(1,2-dialkyl)-4-chloro-5-nitroimidazoles.
Similar content being viewed by others
References
Brit. Pat. 878646;Chem. Abstr.,56:15523a (1962).
Brit. Pat. 973007;Ref. Zh. Khim., 14H303 (1966).
M. Negwer,Organic-Chemical Drugs and Their Synonyms, Academie-Verlag, Berlin (1994), Vol. 1, p. 296.
G. V. Petrov and V. M. Man'ko,Immunodepressants [in Russian], Meditsina, Moscow (1971), p. 31.
L. N. Filitis, Yu. A. Sorokina, G. N. Pershin, L. A. Pevnitskii, V. V. Solov'ev, and L. N. Fontalin,Pharmakol. Toksikol.,34, 708 (1971).
G. D. Daves, C. W. Noell, R. K. Robins, H. C. Koppel, and A. G. Beaman,J. Am. Chem. Soc. 82, 2633 (1960).
P. M. Kochergin,Khim. Geterotsikl. Soedin., No. 5, 761 (1965).
V. S. Korsunskii, P. M. Kochergin, and V. S. Shlikhunova,Khim.-Farm. Zh.,23, 249 (1989).
P. M. Kochergin, A. M. Tsyganova, and V. S. Shlikhunova,Khim.-Farm. Zh., No. 10, 22 (1968).
P. M. Kochergin, E. V. Aleksandrova, V. S. Korsunskii, and V. S. Shlikhunova,Khim. Geterotsikl. Soedin., No. 2, 217 (2000).
Author information
Authors and Affiliations
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 221–224, February, 2000.
Rights and permissions
About this article
Cite this article
Kochergin, P.M., Aleksandrova, E.V., Korsunskii, V.S. et al. Synthesis of 2-amino-6-(nitroimidazolyl)thiopurines. Chem Heterocycl Compd 36, 182–184 (2000). https://doi.org/10.1007/BF02283549
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02283549