Conclusion
From this investigation it is evident that most strains ofC. diphtheriae can be easily typed; with the typing of some strains difficulties have been encountered. By close examination of the properties some of these can be typed after some delay, superisolation being indispensable.
The use of insoluble starch is essential in the fermentation test. All bacteria which differ in one or more respects from the typical ones must be labelled as atypical. This also concerns gravis strains which do not ferment starch and glycogen. If the bacteria are thus typed erroneous typing can be minimized, though faults will be inevitable.
The typical as well as the atypical bacteria have great stability. For the moment we wish to consider the types as fixates rather than as subspecies. Notwithstanding the observation of changesin vitro in some cases, the types appear to be sufficiently stable for epidemiological investigation.
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Stoppelman, M.R.H. On the variability of the types ofC. diphtheriae . Antonie van Leeuwenhoek 14, 173–183 (1948). https://doi.org/10.1007/BF02272690
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DOI: https://doi.org/10.1007/BF02272690