Skip to main content
SpringerLink
Log in

Simultaneous determination of acetylsalicylic acid and salicylic acid by gas-liquid chromatography using a new methylation technique

  • Originals
  • Published:
Chromatographia Aims and scope Submit manuscript

Summary

A GLC method of simultaneous determination of acetylsalicylic acid and salicylic acid after a simple and elegant methylation is presented. Acetonic solution of these acids is refluxed with methyl iodide and potassium carbonate for 30 minutes and then gas chromatographed with a column of 3% OV 17 on Varaport 30, 70–80 mesh, AW/DMCS. The methylation is quantitative in 0.001–0.1 M solutions. The detection limit is about 25 ng.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature

  1. Nikelly, Y. G., Anal. Chem.36, 2248 (1964)

    Article  Google Scholar 

  2. Patel, S., Perrin, J. H., undWindheuser, J. J., J. Pharm. Sci.61, 1794 (1972).

    PubMed  Google Scholar 

  3. Rowland, M., Riegelman, S., J. Pharm. Sci.56, 717 (1967).

    PubMed  Google Scholar 

  4. Thomas, B. H., Solomonraj, G., undColdwell, B. B., J. Pharm. Pharmac.25, 201 (1973).

    Google Scholar 

  5. Watson, J. R., Crescuolo, P., undMatsui, F., J. Pharm. Sci.60, 454 (1971).

    PubMed  Google Scholar 

  6. Crippen, R. D., Freimuth, H. D., Anal. Chem.36, 273 (1964).

    Google Scholar 

  7. Claisen, L., Eisleb, O., Liebigs Ann. Chem.401, 29 (1913).

    Google Scholar 

  8. Dünges, W., Chromatographia4, 197 (1973).

    Google Scholar 

  9. Dünges, W., Bergheim-Irps, E., Analyt. Lett., in press.

  10. Work in progress

Download references

Author information

Authors and Affiliations

  1. Zentrallaboratorium Deutscher Apotheker, Beethovenplatz 1-3, D-6, Frankfurt/Main, West-Germany

    S. Laik Ali

Authors
  1. S. Laik Ali
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ali, S.L. Simultaneous determination of acetylsalicylic acid and salicylic acid by gas-liquid chromatography using a new methylation technique. Chromatographia 6, 478–480 (1973). https://doi.org/10.1007/BF02268988

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02268988

Keywords

Search

Navigation