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HPLC determination of urinary 2,4- and 2,6-toluendiamines as potential degradation products of polyurethane breast implants

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Summary

A reversed-phase HPLC method has been developed for the urinary determination of mutagenic 2,4- and 2,6-toluendiamines. These amines are degradation products of polyurethane, a material used to cover textured silicone breast implants. FMOC-Cl was used as fluorescent derivatising agent in order to obtain a limit of detection of 15 ng/ml in urine. Pre-treatment of urine samples was by liquid/liquid extraction and urine specimens of patients after surgury were analysed.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy

    E. De Lorenzi, G. Massolini & G. Caccialanza

  2. Department of Pharmaceutical Sciences, University of Pisa, Via Bonanno 6, 56100, Pisa, Italy

    M. Macchia

Authors
  1. E. De Lorenzi
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  2. G. Massolini
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  3. M. Macchia
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  4. G. Caccialanza
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De Lorenzi, E., Massolini, G., Macchia, M. et al. HPLC determination of urinary 2,4- and 2,6-toluendiamines as potential degradation products of polyurethane breast implants. Chromatographia 41, 661–664 (1995). https://doi.org/10.1007/BF02267801

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  • DOI: https://doi.org/10.1007/BF02267801

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