Abstract
Using mathematical modeling of the process of generation of a miniature end-plate current (MEPC), we studied the effect of acetylcholinesterase (AChE) inhibition on the amplitude and frequency parameters of synaptic signals in the neuromuscular junction. The density of acetylcholine receptors on the postsynaptic membrane and the number of acetylcholine molecules in its quantum were varied. AChE inhibition against the background of a decreased receptor density was shown to result in a much higher increase in the amplitude of modeled MEPC than that in control and in the case of the changed transmitter amount released in the synaptic cleft. The simulation data can be used as a theoretical background for interpretation of the reason for different efficiencies of AChE inhibitors in certain pathological states of the neuromuscular apparatus.
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Neirofiziologiya/Neurophysiology, Vol. 28, No. 4/5, pp. 186–192, July–October, 1996.
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Kovyazina, I.V., Giniatullin, R.A., Nikol'skii, E.E. et al. Acetylcholinesterase inhibition in neuromuscular synapses in different background states: model studies. Neurophysiology 28, 145–150 (1996). https://doi.org/10.1007/BF02262776
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DOI: https://doi.org/10.1007/BF02262776