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The use of tandem-mass spectrometry for pilot identification

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Summary

The direct analysis of mixtures by tandem-mass spectrometry assisted by off-line liquid chromatographymass spectrometry is already established as a rapid specific and extremely sensitive method that can be applied to samples of a variety of types for example, to analyses of main compounds and by-products in reaction mixtures, to products in medicated solutions or to fermentation products in more or less complex matrices. The techniques are demonstrated as pilot methods for obtaining structural information for identification or structure elucidation.

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References

  1. T. Hirschfeld, Anal. Chem.52, 297A (1980).

    Google Scholar 

  2. N. Gochman, L. J. Bowie, Anal. Chem.51, 525A (1979).

    Google Scholar 

  3. P. J. Arpino, G. Guiochon, Anal. Chem.51, 682A (1979).J. D. Henion, J. Chromatogr. Sci.19, 57 (1981).W. H. McFadden, J. Chromatogr. Sci.18, 97 (1980).

    Google Scholar 

  4. R. G. Cooks, Chem. Eng. News, Nov. 40 (1981).D. F. Hunt, J. Shabanowitz, A. B. Giordani, Anal. Chem.52, 386 (1980).G. J. Louter, A. J. H. Boerboom, P. F. M. Stalmeier, F. W. McLafferty, E. R. Lory, J. Chromatogr.203, 109 (1981).D. H. Russel, E. H. McBay, T. R. Mueller, Internat. Laboratory, April 49 (1980).H. H. Tuithof, J. Kistemaker, Int. J. Mass Spectrom. Ion Phys.33, 335 (1980).V. Vrscaj, J. H. Beynon, T. Ast, Int. J. Mass Spectron. Ion Phys.33, 409 (1980).

  5. D. Dixon this issue and [3].J. D. Henion, J. Chromatogr. Sci.19, 57 (1981).

    Google Scholar 

  6. D. F. Hunt, J. Shabanowitz, F. K. Botz, D. A. Brent, Anal. Chem.49, 1160 (1977).

    Article  Google Scholar 

  7. H. R. Schulten, Int. J. Mass Spectrom. Ion Phys.32, 97 (1979).

    Article  Google Scholar 

  8. M. Barber, R. S. Bordoli, R. D. Sedgwick, A. Tyler, E. I. Walley, Biomed. Mass Spectrom.8, 337 (1981).

    Article  Google Scholar 

  9. T. Matsuo, H. Matsua, Anal. Chem.53, 416 (1981).

    Google Scholar 

  10. D. Fraisse, F. Maquin, D. Stahl, K. Suon, J. C. Tabet, J. Chromatogr. in press.

  11. H. R. Schulten, Int. J. Mass Spectrom. Ion Phys.32, 102 (1979).

    Article  Google Scholar 

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Authors and Affiliations

  1. Pharmaceutical Division, Preclinical Research, Sandoz Ltd, CH-4002, Basle, Switzerland

    Th. Düblin, Ch. Quiquerez & A. Wehrli

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  1. Th. Düblin
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  2. Ch. Quiquerez
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  3. A. Wehrli
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Düblin, T., Quiquerez, C. & Wehrli, A. The use of tandem-mass spectrometry for pilot identification. Chromatographia 15, 414–418 (1982). https://doi.org/10.1007/BF02261600

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  • DOI: https://doi.org/10.1007/BF02261600

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