Summary
A classical plate-type model developed to simulate the separation of binary mixtures by sequential semicontinuous chromatography is modified by the inclusion of a separate expression to account for the effects of solute concentration on the feed plate. The improved model is tested on three systems of different separation difficulty, for which experimental data are available. Comparison of experimental and simulated separations is achieved by consideration of the solute concentration profiles. In determining the success of the simulation, particular note is made of profile shape, feed point location and concentration levels. Best agreement between experimental and simulated profiles is shown to exist for high separation factor systems at low flowrates and low temperatures. Relatively poor agreement for difficult systems at higher flowrates is attributed to phase changes, column temperature effects and the influence of the anti-Langmuir shape of the absorption isotherm.
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References
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S. E. Liodakis, Ph. D. Thesis, University of Aston in Birmingham, 1978.
R. E. Deeble, Ph. D. Thesis, University of Aston in Birmingham, 1974.
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Barker, P.E., Howari, M.I. & Irlam, G.A. Further developments in the modelling of a sequential chromatographic refiner unit. Chromatographia 14, 192–196 (1981). https://doi.org/10.1007/BF02260151
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DOI: https://doi.org/10.1007/BF02260151