Summary
Separation of positional and cis-trans-isomers of tetrahydro-1,5-benzothiazepines and tetrahydro-1,5-benzodiazepines was studied using reversed-phase chromatography and liquid-solid chromatography. The selection of solvent was based on the selective triangle for solvents. Systems of separation consisted of C18 columns and methanol, THF or acetonitrile in water for the reversedphase method; it was suitable for the separation of positional isomers only but the liquid-solid method was suitable for separation of cis-trans-isomers as well as positional isomers using a silica column and ethyl ether, chloroform or ethyl acetate as the mobile phase respectively.
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Jin, HL., Zhang, YL., Guo, Y. et al. HPLC separation of isomers of tetrahydro-1,5-benzothiazepines and tetrahydro-1,5-benzodiazepines. Chromatographia 22, 153–156 (1986). https://doi.org/10.1007/BF02257317
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DOI: https://doi.org/10.1007/BF02257317