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Antioxidant and antiviral activities ofEuphorbia thymifolia L.

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Journal of Biomedical Science

Abstract

The antioxidant and antiviral activities ofEuphorbia thymifolia L. (Euphorbiaceae) were investigated in this study. The results showed that all of the fractions (MeOH, CHCl3, EtOAc, n-butanol and water) and pure compounds (3-O-galloyl-4,6-(S)-HHDP-D-glucose, rugosin B and 1,3,4,6-tetra-O-galloyl-K-β-D-glucose)tested possessed antioxidant activities, with the exception of the organic aqueous fraction in the anti-lipid and anti-super-oxide formation assays. The range of IC50 of anti-lipid formation, anti-superoxide formation and free radical scavenging assays for all fractions and pure compounds were 2.81–7.63, 0.03–2.18 and 0.013–2.878 mg/ml, respectively. Electron spin resonance studies showed that water extract and pure compounds ofE. thymifolia exhibited superoxide radical and hydroxyl radical scavenging activities. Besides antioxidant activities, 3-O-galloyl-4,6-(S)-HHDP-D-glucose and EtOAc fraction also showed anti-HSV-2 activity. Thus,E. thymifolia was concluded to possess antioxidant and anti-HSV-2 activities.

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Authors and Affiliations

  1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung

    Chun-Ching Lin & Chien-Min Yang

  2. Graduate Institute of Pharmaceutical Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung

    Hua-Yew Cheng

  3. Department of Pharmacy, Ta-Jen Institute of Technology, Ping-Tung, Taiwan, ROC

    Ta-Chen Lin

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  1. Chun-Ching Lin
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Lin, CC., Cheng, HY., Yang, CM. et al. Antioxidant and antiviral activities ofEuphorbia thymifolia L.. J Biomed Sci 9, 656–664 (2002). https://doi.org/10.1007/BF02254994

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  • DOI: https://doi.org/10.1007/BF02254994

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