Abstract
A preparative method of synthesis of 2-substituted thieno[2,3-d]pyrimidin-4-ones involving deamination of the corresponding 3-amino derivatives, by sodium nitrite in acidic medium is proposed. A possible reaction mechanism is considered.
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References
F. Sauter, P. Stanetty, H. Potuzak, and M. Baradar,Monatsh. Chem.,107, 669 (1976).
Fr. Demande 2035768;Chem. Abstr.,75, 129830 (1971).
A. P. Mkrtchyan, Author's Abstract of a Candidate Dissertation in Chemical Sciences, Erevan (1980).
D. L. Temple, Bristol-Myers Co., Swiss Patent 638527;RZhKh, No. 9, O134 (1984).
M. Parrisin,Eur. J. Med., Chem.,19, 420 (1984).
A. P. Mkrtchyan, S. G. Kazaryan, A. S. Noravyan, S. A. Vartanyan, I. A. Dzhagatspanyan, I. E. Akopyan, and I. M. Nazaryan,Khim.-Farm. Zh., No. 4, 451 (1984).
A. P. Mkrtchyan, S. G. Kazaryan, A. S. Noravyan, S. A. Vartanyan, I. A. Dzhagatspanyan, and N. E. Akopyan,Arm. Khim. Zh., No. 9, 581 (1987).
A. P. Mkrtchyan, S. G. Kazaryan, A. S. Noravyan, R. A. Akopyan, I. A. Dzhagatspanyan, N. E. Akopyan, and L. G. Akopyan,Khim.-Farm. Zh., No. 11, 1312 (1986).
A. P. Mkrtchyan, S. G. Kazaryan, A. S. Noravyan, R. A. Akopyan, I. A. Dzhagatspanyan, N. E. Akopyan, and A. G. Akopyan,Khim.-Farm. Zh., No. 5, 557 (1985).
J. Honzi and J. Budinger,Coll. Czech. Chem. Commun.,26, 2333 (1961).
A. D. Broom and R. K. Robins,J. Org. Chem.,34, 1025 (1969).
A. S. Noravyan, A. P. Mkrtchyan, I. A. Dzhagatspanyan, I. A. Nazaryan, N. E. Akopyan, and S. A. Vartanyan,Khim.-Farm. Zh., No. 8, 20 (1977).
K. Gewald,Khim. Geterotsikl. Soedin., No. 10, 1299 (1976).
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A. L. Mndzhoyan Institute of Fine Organic Chemistry. Academy of Sciences of the Republic of Armenia, Erevan 375014 Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 941–944, July, 1999.
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Kazaryan, S.G., Noravyan, A.S. & Gevorkyan, G.A. Synthesis of condensed derivatives of 2-substituted thieno[2,3-d]pyrimidin-4-ones. Chem Heterocycl Compd 35, 825–828 (1999). https://doi.org/10.1007/BF02252109
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DOI: https://doi.org/10.1007/BF02252109