Abstract
A convenient method of obtaining Boc-L-Ala-D-iGln-OBzl and its amide analogs by condensing the N-hydroxysuccinimidyl ester of Boc-L-Ala with the γ-benzyl ester ofD-Glu in the presence of NaHCO3, followed by amidation of the resulting Boc-L-Ala-D-Glu-γ-OBzl, is proposed. The use of l-adamantylamine and octadecylamine as amino components has enabled the corresponding α-adamantylamide and octadecylamide of the dipeptide to be obtained.
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Simferopol' State University, 4 Yaltinskaya ul., Simferopol', Crimea, Ukraine 333036. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 101–103, January–February, 1998.
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Zemlyakov, A.E. Synthesis of γ-benzyltert-butoxycarbonyl-L-alanyl-D-glutamate and its derivatives. Chem Nat Compd 34, 78–79 (1998). https://doi.org/10.1007/BF02249692
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DOI: https://doi.org/10.1007/BF02249692