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Conditioned morphine withdrawal in the hamster

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Abstract

Conditioned withdrawal among golden Syrian hamsters was studied in two experiments. In experiment 1, morphine-pelleted (75 mg) hamsters were observed for signs of withdrawal (wet-dog shakes, etc.) before and after a naloxone (1 mg/kg) injection that was administered in a distinctive environment. Withdrawal signs that occurred in the distinctive environment before the naloxone injection were defined as anticipatory conditioned withdrawal responses. Two, 9, and 30 days following pellet removal, retention of conditioned withdrawal responding was assessed in the distinctive environment before and after a saline injection. Results indicated that: a) withdrawal intensity was a direct function of the number of implanted pellets; b) conditioned withdrawal occurred among animals withdrawn in the distinctive environment, but not among those withdrawn in the home cage; c) conditioned withdrawal was a non-monotonic function of precipitated withdrawal intensity; d) conditioned withdrawal was evident up to 30 days after pellet removal. In experiment 2, conditioned withdrawal was extinguished by repeated exposure to the distinctive environment in the absence of precipitated withdrawal. It was concluded that environmental stimuli associated with theabsence of morphine (i.e., precipitated withdrawal) elicit conditioned withdrawal. The results are compared to similar findings in rats and humans.

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References

  • Baker TB, Tiffany ST (1985) Morphine tolerance as habituation. Psychol Rev 92:78–108

    Google Scholar 

  • Baker TB, Morse E, Sherman JE (1986) The motivation to use drugs: a psychobiological analysis of urges. In: Rivers C (ed) Nebraska symposium on motivation. University of California Press, Berkeley, CA, pp 257–323

    Google Scholar 

  • Blasig J, Herz A, Reinhold K, Zieglgansberger S (1973) Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats. Psychopharmacologia 33:19–38

    Google Scholar 

  • Bozarth MA, Wise RA (1984) Anatomically distinct opiate receptor fields mediate reward and physical dependence. Science 224:516–517

    Google Scholar 

  • Childress AR, McLellan AT, Ehrman R, O'Brien CP (1988) Classically conditioned responses in opioid and cocaine dependence: a role in relapse? In: Ray BA (ed) Learning factors in substance abuse. NIDA research monograph no. 84, United States Government Printing Office, Washington DC, pp 25–43

    Google Scholar 

  • Cicero TJ, Meyer ER (1973) Morphine pellet implantation in rats: quantitative assessment of tolerance and dependence. J Pharmacol Exp Ther 184:404–408

    Google Scholar 

  • Collins KH, Tatum AL (1925) A conditioned reflex established by chronic morphine poisoning. Am J Physiol 74:14–15

    Google Scholar 

  • Davis WM, Smith SG (1976) Role of conditioned reinforcers in the initiation, maintenance and extinction of drug seeking behavior. Pavlov J Bio Sci 11:222–236

    Google Scholar 

  • Goldberg SR, Schuster CR (1967) Conditioned suppression by a stimulus associated with nalorphine in morphine-dependent monkeys. J Exp Anal Behav 10:235–242

    Google Scholar 

  • Goldberg SR, Schuster CR (1970) Conditioned nalorphine-induced abstinence changes: persistence in post morphine-dependent monkeys. J Exp Anal Behav 14:33–46

    Google Scholar 

  • Goode PG (1971) An implanted reservoir of morphine solution for rapid induction of physical dependence in rats. Br J Pharmacol 41:558–566

    Google Scholar 

  • Goudie AJ, Demellweek C (1986) Conditioning factors in drug tolerance. In: Goldberg SR, Stolerman IP (eds) Behavioral analysis of drug dependence. Academic Press, New York, pp 225–286

    Google Scholar 

  • Grabowski J, O'Brien CP (1981) Conditioning factors in opiate use. In: Mello NK (ed) Advances in substance abuse, vol 2. JAI Press, Greenwich, CT, pp 69–121

    Google Scholar 

  • Huffman RD, Simmons KE, Lum JT (1985) An intraventricular infusion model for inducing morphine dependence in rats: quantitative assessment of precipitated withdrawal. Behav Neurosci 99:861–880

    Google Scholar 

  • Kalivas PW, Duffy P (1988) Effects of daily cocaine and morphine treatment on somatodendritic and terminal field dopamine release. J Neurochem 50:1498–1504

    Google Scholar 

  • Koga Y, Inukai T (1981) Assessment of physical dependence-inducing capacity of narcotic agonists and antagonists in rats by intermittent infusion technique. Psychopharmacology 73:236–239

    Google Scholar 

  • Koob GF, Wall TL, Bloom FE (1989) Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal. Psychopharmacology 98:530–534

    Google Scholar 

  • Lindesmith A (1968) Addiction and opiates, 2nd edn. Aldine, Chicago

    Google Scholar 

  • Mackintosh NJ (1974) The psychology of animal learning. Academic Press, New York

    Google Scholar 

  • Martin WR, Wikler A, Eades CG, Pescor FT (1963) Tolerance to and physical dependence on morphine in rats. Psychopharmacologia 4:247–260

    Google Scholar 

  • Meyer RE, Mirin SM (1979) The heroin stimulus. Plenum Press, New York

    Google Scholar 

  • O'Brien CP (1975) Experimental analysis of conditioning factors in human narcotic addiction. Pharmacol Rev 27:535–543

    Google Scholar 

  • O'Brien CP, Testa T, O'Brien TJ, Greenstein R (1976) Conditioning in human opiate addicts. Pavlov J Biol Sci 11:195–202

    Google Scholar 

  • O'Brien CP, Testa T, O'Brien TJ, Brady JP, Wells B (1977) Conditioned narcotic withdrawal in humans. Science 195:1000–1002

    Google Scholar 

  • O'Brien CP, Ehrman RN, Ternes JW (1986) Classical conditioning in human opioid dependence. In: Goldberg SR, Stolerman IP (eds) Behavioral analysis of drug dependence. Academic Press, New York, pp 329–356

    Google Scholar 

  • Pavlov IP (1927) Conditioned reflexes. Oxford University Press, Oxford, England

    Google Scholar 

  • Rozin P, Kalat JW (1971) Specific hungers and poison avoidance as adaptive specializations of learning. Psychol Rev 78:459–486

    Google Scholar 

  • Schnur P (1991) Acute morphine dependence in the hamster. Pharmacol Biochem Behav 38:711–713

    Google Scholar 

  • Schnur P, Martinez RA (1989) Environmental control of morphine tolerance in the hamster. Anim Learn Behav 17:322–327

    Google Scholar 

  • Seligman MEP (1970) On the generality of laws of learning. Psychol Rev 77:406–418

    Google Scholar 

  • Sherman SI, Zinser MC, Sideroff SI, Baker TB (1989) Subjective dimensions of heroin urges: Influence of heroin-related and affectively negative stimuli. Addict Behav 14:611–623

    Google Scholar 

  • Sideroff SI, Jarvick ME (1980) Conditioned responses to a videotape showing heroin related stimuli. Int J Addict 15:529–536

    Google Scholar 

  • Siegel S (1976) Morphine analgesic tolerance: its situation specificity supports a Pavlovian conditioning model. Science 193:323–325

    Google Scholar 

  • Siegel S (1977) Morphine tolerance acquisition as an associative process. J Exp Psychol [Anim Behav Proc] 3:1–13

    Google Scholar 

  • Siegel S (1983) Classical conditioning, drug tolerance and dependence. in: Smart RG, Glaser FB, Israel Y, Kalant H, Popham RE, Schmidt (eds) Research advances in alcohol and drug problems. Plenum Press, New York, pp 207–246

    Google Scholar 

  • Stewart J, Eikelboom R (1987) Conditioned drug effects. In: Iverson LL, Iverson SD, Snyder SH (eds) Handbook of psychopharmacology: new directions in behavioral pharmacology, vol 19: Behavioral pharmacology. Plenum Press, New York, pp 1–57

    Google Scholar 

  • Stewart J, de Wit H, Eikelboom R (1984) Role of unconditioned and conditioned drug effects in the self administration of opiates and stimulants. Psychol Rev 91:251–268

    Google Scholar 

  • Teasdale J (1973) Conditioned abstinence in narcotic addicts. Int J Addict 8:273–292

    Google Scholar 

  • Thompson T, Ostlund W (1965) Susceptibility to readdiction as a function of the addiction and withdrawal environments. J Comp Physiol Psychol 60:388–392

    Google Scholar 

  • Tilson HA, Rech RH, Stolman S (1973) Hyperalgesia during withdrawal as a means of measuring the degree of dependence in morphine dependent rats. Psychopharmacologia 28:287–300

    Google Scholar 

  • Wikler A (1948) Recent progress in research on the neurophysiological basis of morphine addiction. Am J Psychiatry 105:328–338

    Google Scholar 

  • Wikler A (1965) Conditioning factors in opiate addiction and relapse. In: Wilner DM, Kassebaum GG (eds) Narcotics. McGraw-Hill, New York, pp 85–100

    Google Scholar 

  • Wikler A (1973) Conditioning of successive adaptive responses to the initial effects of drugs. Conditional Reflex 8:193–210

    Google Scholar 

  • Wikler A, Pescor FT (1967) Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid drinking behavior and “relapse” in morphine addicted rats. Psychopharmacologia 10:255–284

    Google Scholar 

  • Wikler A, Pescor FT, Miller D, Norrell H (1971) Persistent potency of a secondary (conditioned) reinforcer following withdrawal of morphine from physically dependent rats. Psychopharmacologia 20:103–117

    Google Scholar 

  • Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469–492

    Google Scholar 

Download references

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  1. Department of Psychology, University of Southern Colorado, 81001-4901, Pueblo, CO, USA

    Paul Schnur

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Schnur, P. Conditioned morphine withdrawal in the hamster. Psychopharmacology 107, 517–522 (1992). https://doi.org/10.1007/BF02245265

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  • DOI: https://doi.org/10.1007/BF02245265

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