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Effects of secretin on gastric secretion

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Summary

The effect of secretin on gastric secretory activity was studied in three dogs with Heidenhain pouches. A secretory plateau was elicited either by meat-feeding or by continuous administration of histamine. The effects of secretin were evaluated by comparison with identically performed control experiments in which saline alone was administered. Secretin inhibited free acid output by an average of 66% (single dose) and 51% (continuous injection), but even in large doses did not alter histamine-stimulated secretion. Inhibition by secretin was not affected by pancreatic-duct ligation. It is concluded that secretin (1) is a potent gastric secretory inhibitor; (2) is not the agent mediating gastric inhibition by fat or acid; (3) does not affect gastric secretion via the exocrine pancreas.

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Authors and Affiliations

  1. From the Department of Surgery, University of Kentucky Medical Center, Lexington, Ky.

    W. A. Gryroski M.D. & René Menguy M.D., Ph.D.

Authors
  1. W. A. Gryroski M.D.
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  2. René Menguy M.D., Ph.D.
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Additional information

Supported, in part, by N.I.H. Grants A-5713 and AM-5730-02 and American Cancer Society Grant E-186 B.

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Gryroski, W.A., Menguy, R. Effects of secretin on gastric secretion. Digest Dis Sci 9, 87–91 (1964). https://doi.org/10.1007/BF02243511

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  • DOI: https://doi.org/10.1007/BF02243511

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