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Influence of route of administration on therapeutic ratio of atropine in sham-fed dogs

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Summary

Salivary and gastric secretory inhibition were studied simultaneously in 3 sham-fed dogs using atropine by 3 methods of administration.

The relationship of salivary inhibition to gastric inhibition was not parallel, varying with the method of administration.

It is concluded that continuous intravenous infusion of atropine may be an effective method of inhibiting gastric secretion without inhibiting salivary secretion.

The possible significance of this study for peptic ulcer research is discussed.

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Author information

Authors and Affiliations

  1. From the Gastrointestinal Laboratory and Department of Surgery, University of Kansas Medical Center, Kansas City, Kans.

    Robert H. Kubin M.D., William R. Keeler M.D. & Arthur P. Klotz M.D.

Authors
  1. Robert H. Kubin M.D.
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  2. William R. Keeler M.D.
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  3. Arthur P. Klotz M.D.
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Additional information

Supported by Grant T 1 AM-5213-07 from the U. S. Public Health Service and a grant from Eli Lilly and Company.

Fellow in Gastroenterology.

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Kubin, R.H., Keeler, W.R. & Klotz, A.P. Influence of route of administration on therapeutic ratio of atropine in sham-fed dogs. Digest Dis Sci 12, 363–370 (1967). https://doi.org/10.1007/BF02241938

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  • DOI: https://doi.org/10.1007/BF02241938

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