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Role of follow-up in management of local recurrences of colorectal cancer

A prospective, randomized study

  • Original Contributions
  • Published:
Diseases of the Colon & Rectum

Abstract

PURPOSE: This prospective, randomized, single-center study was designed to evaluate the influence of follow-up on detection and resectability of local recurrences and on survival after radical surgery for colorectal cancer. METHODS: Between 1987 and 1990, 207 consecutive patients who underwent curative resections for primary untreated large-bowel carcinoma were randomly assigned to a conventional follow-up group (Group A; n=103) and to an intense follow-up group (Group B; n=104). All the patients were followed up prospectively, and the outcome was known for all of them at five years. Patients in Group A were seen at six-month intervals for one year, and once a year thereafter. Patients in Group B were checked every three months during the first two years, at six-month intervals for the next three years, and once a year thereafter. RESULTS: Of the 103 patients in Group A, local recurrence was detected in 20; 9 (13 percent) of these patients had colon cancer, and 11 (29 percent) had rectal cancer. Of the 104 patients in Group B, local recurrence was detected in 26; 12 (16 percent) of these patients had colon cancer, and 14 (45 percent) had rectal cancer. Twelve cases (60 percent) of local recurrence in Group A and 24 cases (92 percent) in Group B were detected at scheduled visits (P<0.05). Local recurrences were detected earlier in patients of Group B (10.3±2.7vs. 20.2±6.1 months;P<0.0003). Curative re-resection was possible in 2 patients (10 percent) in Group A, 1 with colon cancer and 1 with rectal cancer, and in 17 patients (65 percent) in Group B, 6 with colon cancer and 11 with rectal cancer (P<0.01). Of the Group B patients who had curative re-resections of local recurrence, 8 (47 percent) were disease-free and long-term survivors as of the last follow-up, and 2 (11.7 percent) were alive, but with a new recurrence. The 2 patients in Group A who had curative re-resections died as a result of cancer. The five-year survival rate in Group A was 58.3 percent and in Group B was 73.1 percent. The difference is statistically significant (P < 0.02). CONCLUSIONS: Our data support use of an intense follow-up plan after primary resection of large-bowel cancer, at least in patients with rectal cancer.

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Authors and Affiliations

  1. From the Institute of General Surgery, University of Parma, School of Medicine, Parma, Italy

    Nicola Pietra M.D., Ph.D., Leopoldo Sarli M.D., Renato Costi M.D., Choua Ouchemi M.D. & Anacleto Peracchia M.D.

  2. the Institute of Hygiene, University of Parma, School of Medicine, Parma, Italy

    Mario Grattarola M.D.

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  1. Nicola Pietra M.D., Ph.D.
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  2. Leopoldo Sarli M.D.
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  3. Renato Costi M.D.
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  5. Mario Grattarola M.D.
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  6. Anacleto Peracchia M.D.
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Pietra, N., Sarli, L., Costi, R. et al. Role of follow-up in management of local recurrences of colorectal cancer. Dis Colon Rectum 41, 1127–1133 (1998). https://doi.org/10.1007/BF02239434

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