Conclusions
Glucagon given by continuous intravenous infusion consistently decreases the gastric acid and pepsin output of human subjects for several hours. Ten per cent glucose produces varying depressions in gastric acid and pepsin output. In humans, glucose and glucagon together act consistently to raise the gastricpH and to lower the gastric pepsin concentration throughout the period of administration.
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Aided in part by grants C-2578 and A-1785 from the U. S. Public Health Service.
We are grateful to Mrs. Julia Zalokar, of the Bio-Statistics Department, for her evaluation from a statistical standpoint of this material; and to Mr. Joseph Coscia, Mrs. Nancy Iannotti, Mrs. Felicia Mestel, and Miss Bea Pask, for their technical assistance.
Crystalline glucagon, Lot #0358-PA-60923, AX 29821, was kindly supplied by Dr. Glenn W. Irwin, of Lilly Laboratories.
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Solomon, S.P., Spiro, H.M. The effects of glucagon and glucose on the human stomach. Digest Dis Sci 4, 775–786 (1959). https://doi.org/10.1007/BF02237685
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DOI: https://doi.org/10.1007/BF02237685