Abstract
Neurofibromas are benign nerve sheath tumors commonly found in patients afflicted with neurofibromatosis-1. In the absence of multiple neurofibromas or a diagnosis of neurofibromatosis-1, neurofibromas are referred to as solitary and have been reported to involve the skin, subcutaneous tissue, deep soft tissue, and viscera of almost all areas of the body. A neurofibroma involving the anal canal is a rare entity, with only one report in the literature. We present two cases in which large masses involving the anal canal of elderly females were locally resected and proved to be neurofibromas by histopathology. Although rare, these tumors should be considered in the differential diagnosis of patients presenting with an anal mass, because resection alone is the treatment of choice.
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References
Harkin JC, Reed RJ. Tumors of the peripheral nervous system. In: Atlas of Tumor Pathology, series 2, fascicle 3. Washington, D.C.: Armed Forces Institute of Pathology, 1969:29–84.
Kissane JM, ed. Anderson's pathology. 9th ed. Philadelphia: CV Mosby, 1990:1892–4, 2171–3.
Ghosh SK, Ghosh K. Neurofibroma in anal canal. J Indian Med Assoc 1978;71:207–8.
Riccardi VM. Neurofibromatosis. Clinical heterogeneity. Curr Concepts Cancer 1982;8:1–34.
Reznik M. Cutaneous neuropathology: neurofibromas, schwannomas and other neural neoplasms with cutaneous and extracutaneous expressions. Clin Neuropathol 1991;10:225–31.
Gutmann DH, Alysworth A, Carey JC,et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997;278:51–7.
Ghrist TD. Gastrointestinal involvement in neurofibromatosis. Arch Intern Med 1963;112:357–62.
Watanuki F, Ohwada S, Hosomura Y,et al. Small ileal neurofibroma causing intussusception in a non-neurofibromatosis patient. J Gastroenterol 1995;30:113–6.
Morris P, Malt K. Oxford textbook of surgery. New York: Oxford University Press, 1994:1132–3.
Rosai J. Ackerman's surgical pathology. 8th ed. Philadelphia: CV Mosby, 1996:800–14.
Franklin A, Uff JS, Spencer J. Anal neurofibrosarcoma treated with fast neutron irradiation. BMJ 1978;1:959–60.
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Frick, E.J., Lapos, L. & Vargas, H.D. Solitary neurofibroma of the anal canal. Dis Colon Rectum 43, 109–112 (2000). https://doi.org/10.1007/BF02237253
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DOI: https://doi.org/10.1007/BF02237253