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Effect of thyroid hormones on the intestinal transport of valine in vitro

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Summary

Injection of 4 mg. thyroxine on the first day and 8 mg. on the second, third, and fourth days decreased (p<0.05) by the fifth day all the parameters of valine transport in everted intestinal sacs from the rat. Thyroidectomy-parathyroidectomy, 50 days prior to sac studies, profoundly accelerated all the parameters of valine translocation. The injection of 4 µg. of thyroxine daily into the thyroidectomized group reduced the valine transport parameters to control levels. An isolated deficiency in the parathyroid hormones had no significant effect on valine transport. Serum glutamic oxalacetic transaminase levels were found to vary inversely with the thyroid status of the rats.

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Author notes

  1. S. Islam M.D., Ph.D.

    Present address: Nutritional Laboratory, Dacca, East Pakistan

Authors and Affiliations

  1. From the Gastrointestinal Research Laboratory, Departments of Medicine and of Biochemistry, Indiana University School of Medicine, and the Veterans Administration Hospital, Indianapolis, Ind.

    S. Islam M.D., Ph.D., S. Reiser Ph.D. & P. A. Christiansen M.D.

Authors
  1. S. Islam M.D., Ph.D.
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  2. S. Reiser Ph.D.
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  3. P. A. Christiansen M.D.
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Additional information

Supported in part by Grants AM05932 and AM5223 from the National Institutes of Health, U. S. Public Health Service.

We wish to thank Dr. Leo Oliner for the use of the equipment of the Veterans Administration Radioisotope Service.

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Islam, S., Reiser, S. & Christiansen, P.A. Effect of thyroid hormones on the intestinal transport of valine in vitro. Digest Dis Sci 13, 266–274 (1968). https://doi.org/10.1007/BF02236602

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