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Clinical, haematological and pathological studies in donkeys experimentally infected withTrypanosoma brucei

Etudes Clinique, Hemathologique Et Pathologique Chez Des Anes Experimentalement Infectes ParTrypanosoma Brucei

Estudios Clinicos, Hematologicos Y Patologicos En Burros Infectados Experimentalmente ConTrypanosoma Brucei

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Summary

Donkeys experimentally infected withTrypanosoma brucei showed dullness, weakness, fever, inappetence, conjunctivitis, tachycardia and polydyspnoea soon after detectable parasitaemia. The parasitaemia was generally low with transient high peaks except in the terminal stage when there was sustained high parasitaemia. A moderate anaemia was present as from the second week of infection but it was not progressive. There was a marked leucopoenia within 24 h of patent parasitaemia. Death occurred 2 to 21/2 months after infection and at necropsy there was severe emaciation as well as mild serous effusion. Histologically, there was a nonsuppurative encephalomyelitis, cranial neuritis, extensive haemosiderosis, hyperplasia of follicles in lymph nodes and spleen and giant cell reaction in lymph nodes. Trypanosomes were present in the cerebrospinal fluid, the eye and serous effusions.

These observations are similar to those previously reported in other animals infected withT. brucei.

Résumé

Des ânes expérimentalement infectés parT. brucei ont montré, abattement, faiblesse, inappétence, conjonctivite, tachycardie et polypnée peu après que la parasitémie ait été décelée.

La parasitémie a été généralement faible avec des pointes élevées mais de courte durée sauf au dernier stade de la maladie ou existe alors un haut et constant degré de parasitémie.

Une anémie modérée a existé dès la deuxième semaine de la maladie mais n'a pas progressé. Il y a eu une leucopénie marquée dans les 24 heures suivant une parasitémie appréciable. La mort est survenue dans les deux mois à deux mois et demi après l'infection; l'autopsie a montré une sévêre émaciation ainsi que des épanchements séreux peu marqués. Histologiquement, on a observé une encéphalomyélite non suppurative, des signes d'encéphalite, une hémosiderose étendue, l'hyperplasie des follicules lymphoïdes et de la rate ainsi qu'une réaction des cellules géantes dans les ganglions lymphatiques. Les trypanosomes étaient présents dans le liquide cérébro-spinal, les yeux et les épanchements séreux.

Ces observations sont semblables à celles déjà observées chez d'autres animaux infectés parT. brucei.

Resumen

Burros infectados experimentalmente conTrypanosoma brucei presentaron decaimiento, fiebre, inapetencia, conjuntivitis, taquicardia y polidisnea, poco después de evidenciarse la parasitemia. Esta fué generalmente baja con elevaciones transitorias, excepto en los estadios terminales de la enfermedad cuando la parasitemia fué alta y sostenida.

Después de la segunda semana de infección, los animales presentaron anemia moderada la cual no fué progresiva. El cambio clínico más severo fué la leucopenia 24 horas después de la parasitemia cíclica. Los animales murieron entre 2 y 21/2 meses después de la infección, presentando a la necropsia emaciación y efusiones serosas. Los cambios histológicos se caracterizaron por encefalomielitis no supurativa, neuritis craneal, hemosiderosis extensiva, hiperplasia folicular y células gigantes en ganglios linfáticos y bazo. Se encontraron tripanosomas en el líquido cerebroespinal, ojos y efusiones serosas. Estas observaciones son similares a las reportadas previamente en otros animales infectados conT. brucei.

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Authors and Affiliations

  1. Department of Veterinary Pathology and Department of Veterinary Medicine and Surgery, University of Ibadan, Nigeria

    B. O. Ikede, J. U. Akpokodje, D. H. Hill & P. O. A. Ajidagba

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  1. B. O. Ikede
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  2. J. U. Akpokodje
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  3. D. H. Hill
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  4. P. O. A. Ajidagba
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Ikede, B.O., Akpokodje, J.U., Hill, D.H. et al. Clinical, haematological and pathological studies in donkeys experimentally infected withTrypanosoma brucei . Trop Anim Health Prod 9, 93–98 (1977). https://doi.org/10.1007/BF02236387

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  • DOI: https://doi.org/10.1007/BF02236387

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