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Hypertrophy of the small intestine after its partial resection in the rat

Ultrastructure of the intestinal epithelium

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Abstract

The authors investigated the ultrastructure of small intestinal epithelium in the rat, 3 weeks after resection of the proximal half of the small intestine. They sought to determine: (1) whether the compensatory hypertrophy of the mucosa of the residual small intestine results in changes in the microvilli, in addition to prolongation of the villi; and, (2) whether it is possible to provide evidence of less complete morphologic differentiation in the more rapidly migrating enterocytes.

The epithelium on the surface of villi in animals after resection does not differ ultrastructurally from controls and is formed by completely differentiated cellular elements. It is apparent that the compensatory enlargement of the intestinal absorption surface is a result of the hypertrophy of the mucosal villi, and not of changes in the microvilli.

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References

  1. Fábry, P., andKujalová, V. Enhanced growth of the small intestine in rats as a result of adaptation to intermittent starvation.Acta Anat (Basel) 43:264, 1960.

    Google Scholar 

  2. Slabochová, Z., andPlacer, Z. Adaptation of the small intestine to a highfat diet containing saturated and unsaturated fatty acids.Nature (London) 195:380, 1962.

    Google Scholar 

  3. Fisher, J. E. Effects of feeding diets containing lactose, agar cellulose, raw potato starch, or arabinose on the dry weights of cleaned gastrointestinal tract organs in the rat.Amer J Physiol 188:550, 1957.

    Google Scholar 

  4. Fell, B. F., andSmith, K. A., andCampbell, R. M. Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat.J Path Bact 85:179, 1963.

    Google Scholar 

  5. Loran, M. R., Althausen, T. L., andIrvine, E. Effects of “minimal” resection of the small intestine on absorption of vitamin A in the rat.Gastroenterology 31:717, 1956.

    Google Scholar 

  6. Booth, C. C., Evans, K. T., Menzies, T., andStreet, D. F. Intestinal hypertrophy following partial resection of the small bowel in the rat.Brit J Surg 46:403, 1959.

    Google Scholar 

  7. Bochkov, N. P. Morphological changes in the jejunum and ileum of rats after wide resection of the small intestine.Bull Exp Biol Med 47:76, 1959.

    Google Scholar 

  8. Loran, M. R., andAlthausen, T. L. Hypertrophy and changes in cholinesterase activities of the intestine, erythrocytes and plasma after partial resection of the small intestine of the rat.Amer J Physiol 193:516, 1958.

    Google Scholar 

  9. Loran, M. R., andAlthausen, T. L. Cellular proliferation of intestinal epithelia in the rat two months after partial resection of the ileum.J Biophys Biochem Cytol 7:667, 1960.

    Google Scholar 

  10. Skála, I., Hromádková, V., andSkála, J. “Morphologische Kompensation der Dünndarmresektion bei der Ratte.” InActa tertii conventuus medicinae internae Hungarici (Gastroenterologia), Magyar, I., Ed. Budapest, 1965, p. 238.

    Google Scholar 

  11. Dowling, R. H., andBooth, C. C. Structural and functional changes following small intestinal resection in the rat.Clin Sci 32:139, 1967.

    Google Scholar 

  12. Loran, M. R., andCrocker, T. T. Population dynamics of intestinal epithelia in rat two months after partial resection of ileum.J Cell Biol 19:285, 1963.

    Google Scholar 

  13. Fábry, P. Jednoduchý systém standardních laboratorních diet s různým podílem hlavních živin.Cesk Fysiol 8:529, 1959.

    Google Scholar 

  14. Pearse, D. C. Histological Technics for Electron Microscopy. Acad. Press, London, 1960.

    Google Scholar 

  15. Trier, J. S. Studies on small intestinal crypt epithelium: II. Evidence for and mechanisms of secretory activity by undifferentiated crypt cells of the human small intestine.Gastroenterology 47:480, 1964.

    Google Scholar 

  16. Rubin, W., Ross, L. L., Sleisenger, M. H., andWeser, E. An electron microscopic study of adult celiac disease.Lab Invest 15:1720, 1966.

    Google Scholar 

  17. Brown, A. L., Microvilli of the human jejunal epithelial cell.J Cell Biol 12:623, 1962.

    Google Scholar 

  18. Overton, J., andShoup, J. Fine structure of cell surface specializations in the maturing duodenal mucosa of the chick.J Cell Biol 21:75, 1964.

    Google Scholar 

  19. Malinský, J. Ultrastructure of intestinal mucosa in man under normal conditions, during absorption of iron and fat and during malabsorption.Acta Univ Palackianae Olomusc 39:143, 1965.

    Google Scholar 

  20. Trier, J. S., andRubin, C. E. Electron microscopy of the small intestine: A review.Gastroenterology 49:574, 1965.

    Google Scholar 

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Authors and Affiliations

  1. From the Institute of Human Nutrition and the Institute for Research of Child Development, Pediatric Faculty, Prague, Czechoslovakia

    I. Skála M.D., C.Sc. & V. Konrádová M.D., C.Sc.

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  1. I. Skála M.D., C.Sc.
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  2. V. Konrádová M.D., C.Sc.
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Skála, I., Konrádová, V. Hypertrophy of the small intestine after its partial resection in the rat. Digest Dis Sci 14, 182–188 (1969). https://doi.org/10.1007/BF02235879

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  • DOI: https://doi.org/10.1007/BF02235879

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