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Effect of long-term treatment with an anticholinergic drug on gastric secretion in rats

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Summary

An anticholinergic, propantheline bromide, was given in a dosage of 5 mg./ kg. body weight twice daily to rats. Gastric function was studied after 3, 6, 9, and 12 months of this treatment. Gastric content was collected after (1) pyloric and cardia ligation; (2) pyloric ligation only; and (3) during a 24-hr, intravenous infusion of histamine. Under the experimental conditions described, a significant reduction of gastric secretion was found in rats after long-term administration of propantheline bromide. This is considered due to the impairment of gastric secretory function induced by repeated inhibition of gastric secretion over a prolonged period.

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Authors and Affiliations

  1. From the Surgical-Medical Research Institute, University of Alberta, Edmonlon, Alberta, Canada

    K. Kowalewski Ph.D., M.D.

Authors
  1. K. Kowalewski Ph.D., M.D.
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Additional information

Propantheline bromide (Pro-Banthine) was donated by G. D. Searle & Co., Chicago, Ill.

The technical assistance of Mr. G. Chmm'a, Mrs. E. Dimition and Mrs. M. McCubbin is gratefully acknowledged.

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Kowalewski, K. Effect of long-term treatment with an anticholinergic drug on gastric secretion in rats. Digest Dis Sci 12, 988–993 (1967). https://doi.org/10.1007/BF02233257

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  • DOI: https://doi.org/10.1007/BF02233257

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