Summary
The effect of 4 hr. of localized hypoxia on the electrical activity of intact intestinal segments of unanesthetized dogs was investigated through the use of indwelling platinum electrodes. Slow-wave activity from normal intestinal segments orad and caudad to the perfused segments was conducted only for short distances into the perfused segment. The frequency of the slow waves in the center of the perfused segment was less than the frequency in segments orad or caudad to it. When the influence of the upper duodenal pacemaker was removed from lower duodenal and upper jejunal segments by hypoxic perfusion, the direction of conduction of the slow waves in these lower, non-perfused segments was orad, caudad, or both.
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Taken in part from a thesis submitted by Joseph Szurszewski in partial fulfillment of the requirements for the Ph.D. degree, University of Illinois, Urbana, Ill., and published in part as a preliminary report inFed Proc 25:514, 1966
Supported by Grant 1-F1-GM-29-523 from the National Institutes of Health, U. S. Public Health Service.
The authors wish to thank Dr. Paul Bass, Parke, Davis & Company, for the use of his facilities in order to learn some of the technics used in this research. The senior author is indebted to Professor C. Ladd Prosser for his suggestions and to the department of Physiology and Biophysics. University of Illinois, for the use of its facilities.
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Szurszewski, J., Steggerda, F.R. The effect of hypoxia on the electrical slow wave of the canine small intestine. Digest Dis Sci 13, 168–177 (1968). https://doi.org/10.1007/BF02232959
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DOI: https://doi.org/10.1007/BF02232959