An anticholinergic drug, propantheline bromide, was administered orally and parenterally to Wistar rats for periods of up to 7 months. Gastric acid secretion, measured 48 hr. after discontinuance of the drug, was unchanged in rats that received propantheline orally and increased in those that received the drug parenterally. This increase was associated with greater thickness and surface area of fundic mucosa and reduced weight gain. The development of tolerance to propantheline did not occur.
Public Health Bromide Weight Gain Gastric Acid Acid Secretion
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Hunt, J. N., andWales, R. C. Progress in patients with peptic ulceration treated for more than five years with poldine, including a double blind study.Brit Med J 2:13, 1966.Google Scholar
Dotevall, G., Walan, A., andWeinfeld, A. Effect of 1-hyoscyamine on gastric secretion of acid and intrinsic factor in man.Gut 8:276, 1967.PubMedGoogle Scholar
Card, W. I., andMarks, I. N. The relationship between the acid output of the stomach following “maximal” histamine stimulation and the parietal cell mass.Clin Sci 19:147, 1960.PubMedGoogle Scholar
Posey, E. L., Jr., Elliott, R., Aldridge, J., Turner, C., andFranklin, H. Long-term anticholinergic administration and gastric secretory function in dogs.Amer J Dig Dis 11:421, 1966.CrossRefPubMedGoogle Scholar
Kowaleski, K., andKasper, T. Achlorhydria, gastric mucosal atrophy and gastric neoplastic lesions in rats, mice and hamsters treated with an anticholinergic drug, propantheline bromide, and a carcinogen, 20-methylcholanthrene.Canad J Surg 10:99, 1967.PubMedGoogle Scholar
Roe, J. H., andDwyer, H. M. Relation of nutrition to gastric function. 1. An experimental method.Proc Soc Exp Biol Med 41:603, 1939.Google Scholar
Kowaleski, K. Effect of prolonged administration of an anticholinergic drug on gastric secretion of rats, mice and hamsters.Arch Int Pharmacodyn 152:404, 1964.PubMedGoogle Scholar
Kowalfski, K. Effect of long-term treatment with an anticholinergic drug on gastric secretion in rats.Amer J Dig Dis 12:988, 1967.CrossRefPubMedGoogle Scholar
Shay, H., Komarow, S. A., Fels, S. S., Mfranze, D., Gruenstein, M., andSiplet, H. A simple method for the uniform production of gastric ulceration in the rat.Gastroenterology 5:43, 1945.Google Scholar
Sircus, W. Prolonged augmentation of the maximal secretory responses of canine gastric pouches by chronic obstruction; a preliminary report and hypothesis.Amer J Dig Dis 10:499, 1965.CrossRefPubMedGoogle Scholar
Crean, G. P. InGastric Secretion: Mechanisms and Control. Pergamon, Toronto, Canada, 1967. p. 33.Google Scholar
Barrett, A. M., Raventos, J., andSiddall, R. A. Influence of some anaesthetics on pharmacologically stimulated gastric secretion in the rat.Brit J Pharmacol 28:51, 1966.PubMedGoogle Scholar
Barrett, A. M. Specific stimulation of gastric acid secretion by a pentapeptide derivative of gastrin.J Pharm Pharmacol 18:633, 1966.PubMedGoogle Scholar