The American Journal of Digestive Diseases

, Volume 13, Issue 11, pp 994–1002 | Cite as

Effect of prolonged administration of an anticholinergic drug, propantheline bromide, on gastric histology and acid secretion

  • Michael D. Kaye
  • A. Jacobs
  • H. Ireson
  • D. Trevett


An anticholinergic drug, propantheline bromide, was administered orally and parenterally to Wistar rats for periods of up to 7 months. Gastric acid secretion, measured 48 hr. after discontinuance of the drug, was unchanged in rats that received propantheline orally and increased in those that received the drug parenterally. This increase was associated with greater thickness and surface area of fundic mucosa and reduced weight gain. The development of tolerance to propantheline did not occur.


Public Health Bromide Weight Gain Gastric Acid Acid Secretion 
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1968

Authors and Affiliations

  • Michael D. Kaye
    • 1
  • A. Jacobs
    • 1
  • H. Ireson
    • 1
  • D. Trevett
    • 1
  1. 1.From the Medical Unit and Department of PathologyWelsh National School of Medicine, Cardiff Royal InfirmaryU.K.

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