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Effects of restraint stress on gastric secretion in the rat

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Summary

When rats were stressed by restraint in a wire jacket for 20 hr., hemorrhagic gastric erosions consistently developed in the glandular mucosa. Previously vagotomized rats were partially protected from stress ulcers, whereas hypophysectomy or adrenalectomy were without effect. Measurement of 6-hr. gastric secretory output in rats submitted to the same restraint stress revealed a 94 per cent inhibition of gastric secretory activity in comparison with unstressed controls.

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Authors and Affiliations

  1. From the Department of Surgery, University of Oklahoma Medical Center and Surgical Service, Veterans Administration Hospital, Oklahoma City, Okla

    René Menguy M.D., Ph.D.

Authors
  1. René Menguy M.D., Ph.D.
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Additional information

This investigation was supported in part by Grants A-3317 and A-3012 from the National Institute of Health and Grant E-186 from the American Cancer Society.

John and Mary Markle Scholar in Medical Sciences.

Presented in part at the Second Annual Gastroenterological Research Forum, New Orleans, La., Mar. 31, 1960.

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Menguy, R. Effects of restraint stress on gastric secretion in the rat. Digest Dis Sci 5, 911–916 (1960). https://doi.org/10.1007/BF02232858

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  • DOI: https://doi.org/10.1007/BF02232858

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