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Pancreatic dose response to synthetic secretin and intraduodenal acid in dogs

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Abstract

In 6 dogs with chronic pancreatic fistulas, dose response curves to synthetic secretin and duodenal acidification were obtained for pancreatic volume flow, bicarbonate and chloride secretion. Secretin given intravenously in doses ranging from 0.125 to 2.0µg/kg/hr, either in graded doses on the same day or in single doses given on separate days, produced almost identical response curves. Synthetic secretin produced the highest mean volume flow, 47.0 ml/30 min, and bicarbonate output, 6.31 mEq/30 min, at the dose of 2.0µg/kg/hr. Maximal response to acid infused into the duodenum in the rate from 1 to 16 mEq/hr, either in graded amounts given in 1 day's test or in single amounts given on separate test days, occurred at the rate of 8 mEq/hr. The maximal pancreatic response in tests with single amounts of acid was equal to the highest response to secretin, whereas in tests with graded amounts of acid, it was about 10% lower than the highest response to secretin.

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Authors and Affiliations

  1. Department of Physiology, Medical Academy Cracow, ul. Grzegórzecka 16, Kraków, Poland

    S. J. Konturek MD, J. Tasler MD & W. Obtulowicz MD

Authors
  1. S. J. Konturek MD
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  2. J. Tasler MD
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  3. W. Obtulowicz MD
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Additional information

The authors wish to thank Dr. M. Ondetti of the Squibb Institute for Medical Research, New Brunswick, NJ for the generous supply of synthetic secretin.

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Konturek, S.J., Tasler, J. & Obtulowicz, W. Pancreatic dose response to synthetic secretin and intraduodenal acid in dogs. Digest Dis Sci 15, 987–991 (1970). https://doi.org/10.1007/BF02232817

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  • DOI: https://doi.org/10.1007/BF02232817

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