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The effect of histamine on pepsin secretion

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Summary

1. Histamine stimulates pepsin secretion in man, both the output and concentration rising. In the dog, histamine produces a fall in pepsin concentration and output; some investigators have observed a transient rise in pepsin output preceding a fall. This could be accounted for by a washing out effect.

2. This difference in the effect of histamine on pepsin output in man and dogs is probably a true species difference. If pepsin is secreted continuously, the low or absent basal secretion in the dog makes a washing out effect theoretically possible. Also, there is evidence that histamine may inhibit the action of the peptic cells of the dog.

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Authors and Affiliations

  1. From the Department of Medicine, University of Sydney, and The Unit of Clinical Investigation, The Royal North Shore Hospital of Sydney, Sydney, Australia

    D. W. Piper (M.R.C.P., M.R.A.C.P.)

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  1. D. W. Piper
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This work was supported by a grant from the Post-Graduate Medical Foundation of Sydney.

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Piper, D.W. The effect of histamine on pepsin secretion. Digest Dis Sci 5, 880–888 (1960). https://doi.org/10.1007/BF02232189

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  • DOI: https://doi.org/10.1007/BF02232189

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