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Correlation between urinary levels of histamine metabolites in 24-hour urine and morning urine samples of man: Influence of histamine-rich food

  • Histamine in Cell Proliferation, Cancer and Clinical Studies
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Abstract

In this study, we have determined and correlated the excretion of the 2 most important histamine metabolites, Nτ-methylhistamine and Nτ-methylimidazoleacetic acid, in 24-hour urine and morning urine samples of 14 normal healthy persons. We found no significant difference between morning urine and 24-hour urine samples, provided that the subjects were on a histamine-poor diet for at least 24 hours. We also studied the influence of the consumption of histamine-rich foodstuffs on the reliability of these parameters. The morning urinary Nτ-methylhistamine excretion is less affected by histamine-rich foodstuffs and therefore proposed to be the most reliable parameter for endogeneous histamine release.

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Authors and Affiliations

  1. BCO Centre for Research, P.O.B. 2176, 4800 CD, Breda, The Netherlands

    E. Oosting & J. J. Keyzer

  2. Central Laboratory for Clinical Chemistry, University Hospital, Groningen, The Netherlands

    B. G. Wolthers

Authors
  1. E. Oosting
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  2. J. J. Keyzer
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  3. B. G. Wolthers
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Oosting, E., Keyzer, J.J. & Wolthers, B.G. Correlation between urinary levels of histamine metabolites in 24-hour urine and morning urine samples of man: Influence of histamine-rich food. Agents and Actions 27, 205–207 (1989). https://doi.org/10.1007/BF02222240

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  • DOI: https://doi.org/10.1007/BF02222240

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