Skip to main content
SpringerLink
Log in

Influenza A virus enhances IgE-mediated histamine release from human basophil leukocytes. Examination of the effect of viral neuraminidase and haemagglutinin

  • Histamine Release from Murine Serosal Mast Cells and Human Basophils
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Histamine release caused by anti-IgE was examined in leukocyte suspensions from 10 healthy individuals. Influenza A virus was found to enhance the histamine release but did not release histamineper se. When monoclonal antibodies directed against the viral neuraminidase were included in the samples, the potentiating effect of the virus was completely abolished. The same occurred using a neuraminidase inhibitor. However, monoclonal antibodies directed against the viral haemagglutinin also abolished the potentiation. A binding of virus to the basophil cell surface by haemagglutinin therefore seems to be necessary for the viral neuraminidase to cause potentiation of mediator release.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. Clementsen, C. Hannoun and S. Norn,Influenza A virus enhances allergic histamine release. Effect of neuraminidase. Allergy (in press).

  2. P. Clementsen, C. B. Jensen, J. O. Jarløv, C. Hannoun, M. Søborg and S. Norn,Influenza A virus enhances Staphylococcus aureus-induced basophil histamine release in normal individuals and patients with intrinsic asthma. Allergy (in press).

  3. P. Clementsen, C. B. Jensen, C. Hannoun, M. Søborg and S. Norn,Influenza A virus potentiates basophil histamine release caused by endotoxin-induced complement activation. Examination of normal individuals and patients with intrinsic asthma. Allergy43, 93–99 (1988).

    PubMed  Google Scholar 

  4. P. Clementsen, H. Bisgaard, M. Pedersen, H. Permin, E. Struve-Christensen, N. Milman, B. Nüchel-Petersen and S. Norn,Staphylococcus aureus and influenza A virus stimulate human bronchoalveolar cells to release histamine and leukotrienes. Agents and Actions27, 107–109 (1989).

    PubMed  Google Scholar 

  5. P. Stahl Skov and S. Norn,A simplified method for measuring basophil histamine release and blocking antibodies in hay fever patients. Basophil histamine content and cell preservation. Acta Allergol.32, 170–182 (1977).

    PubMed  Google Scholar 

  6. S. Ida, J. Hooks, R. P. Siraganian and A. L. Notkins,Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J. exp. Med.145, 892–906 (1977).

    PubMed  Google Scholar 

  7. T. Chonmaitree, M. A. Lett-Brown, Y. Tsong, A. S. Goldman and S. Baron,Role of interferon in leukocyte histamine release caused by common respiratory viruses. J. infect. Dis.157, 127–132 (1988).

    PubMed  Google Scholar 

  8. R. Schauer and A. P. Corfield,Sialidases and their inhibitors. In:Medicinal Chemistry Advances. (Ed. F. G. De Las Heras and S. Vega) pp. 423–434. Pergamon Press, Oxford 1981.

    Google Scholar 

  9. D. W. Kingsburgy.Orthomyxo- and Paramyxoviruses and Their Replication. InVirology. (Ed. B. N. Fields) pp. 1157–1178, Raven Press, New York 1985.

    Google Scholar 

  10. W. Weis, J. H. Brown, S. Cusack, J. C. Paulson, J. J. Skehel and D. C. Wiley,Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature333, 426–431 (1988).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Pharmacology, University of Copenhagen, Juliane Maries Vej 20, 2100, Copenhagen Ø, Denmark

    S. Norn

  2. National Institute for Medical Research, Mill Hill, NW7 1AA, London, UK

    P. Clementsen, A. R. Douglas & J. J. Skehel

  3. Unit of Viral Ecology, Institut Pasteur, Paris, France

    C. Hannoun

  4. Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark

    N. Bach-Mortensen

Authors
  1. P. Clementsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. R. Douglas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. J. Skehel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Hannoun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. Bach-Mortensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Norn
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Clementsen, P., Douglas, A.R., Skehel, J.J. et al. Influenza A virus enhances IgE-mediated histamine release from human basophil leukocytes. Examination of the effect of viral neuraminidase and haemagglutinin. Agents and Actions 27, 58–61 (1989). https://doi.org/10.1007/BF02222198

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02222198

Keywords

Search

Navigation