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Some effects of dieldrin and mirex on Ehrlich ascites tumor cellsin vivo andin vitro

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Abstract

The effects of dieldrin and mirex on Ehrlich ascites tumor cells were assessed, using certainin vivo (in mice) andin vitro measurements. Mirex retarded the development of Ehrlich ascites tumorin vivo, but dieldrin did not. Effects of dieldrin onde novo RNA purine synthesis from formatein vivo were slight, while mirex inhibited the synthesis of both RNA purines. Dieldrin inhibited thein vitro incorporation of thymidine, uridine, and L-leucine into DNA, RNA, and protein, respectively, but mirex was virtually without effect.

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Abbreviations

DMSO:

dimethyl sulfoxide

MEM:

Eagle's minimum essential medium with Hanks' balanced salt solution

TPCV:

total packed cell volume of Ehrlich ascites tumor cells

DNA:

deoxyribonucleic acid

RNA:

ribonucleic acid

ip:

intraperitoneally

p, p′-DDT:

2, 2-bis(4-chlorophenyl)-1,1,1-trichloroethane

o, p′-DDT:

2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1, 1-trichloroethane

References

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Authors and Affiliations

  1. Department of Pathology, Medical University of South Carolina, USA

    Ernest M. Walker Jr.

  2. Department of Pharmacology, Medical University of South Carolina, USA

    Glen R. Gale & Loretta M. Atkins

  3. Department of Clinical Pathology, Medical University of South Carolina, USA

    Richard H. Gadsden

  4. Veterans Administration Hospital, 29403, Charleston, South Carolina

    Glen R. Gale & Loretta M. Atkins

Authors
  1. Ernest M. Walker Jr.
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  2. Glen R. Gale
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  3. Loretta M. Atkins
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  4. Richard H. Gadsden
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Walker, E.M., Gale, G.R., Atkins, L.M. et al. Some effects of dieldrin and mirex on Ehrlich ascites tumor cellsin vivo andin vitro . Arch. Environ. Contam. Toxicol. 5, 333–341 (1977). https://doi.org/10.1007/BF02220915

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  • DOI: https://doi.org/10.1007/BF02220915

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