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Effects of sodium naproxen on differentiated human chondrocytes cultivated in clusters

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Summary

The effects of different pharmacological concentrations of the nonsteroidal anti-inflammatory drug (NSAID) sodium naproxen (NAP) were tested on several metabolic functions of differentiated human chondrocytes cultivated in clusters and compared with the action of acetylsalicylic acid (ASA). DNA synthesis was significantly inhibited by ASA but not by NAP. Proteoglycan production was also markedly decreased by ASA, while synthesis of type II collagen was not modified. By contrast, NAP did not affect these chondroformative processes. Both NSAIDs were potent inhibitors of prostaglandin E2 production. These results indicate that in terms of the parameters tested NAP does not lead to deleterious effects on human articular chondrocytes cultured in vitro.

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  1. Department of Rheumatology, Laboratory of Radioimmunoassay, University of Liège, CHU B-23, Sart-Tilman par Liège 1, Liège, Belgium

    C. Bassleer, Y. Henrotin &  P. Franchimont

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Bassleer, C., Henrotin, Y. & Franchimont, P. Effects of sodium naproxen on differentiated human chondrocytes cultivated in clusters. Clin Rheumatol 11, 60–65 (1992). https://doi.org/10.1007/BF02207086

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