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Hypnotics and sleep physiology: A consensus repot

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Summary

The effects of hypnotics on descriptive and functional aspects of electrophysiological sleep parameters are assessed in this report. Because of the arbitrary definition of some of the criteria underlying the conventional sleep stage scoring procedure, computer-aided methods of EEG analysis have become increasingly important for recording and interpreting pharmacological effects on sleep. Of particular interest are the changes of EEG slow-wave activity, since this parameter varies as a function of prior sleep and waking. Several types of interaction between hypnotics and sleep regulation are discussed, some recent pharmacological developments are highlighted, and some common problems in clinical trials are specified.

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References

  • Achermann P, Borbély AA (1987) Dynamics of EEG slow wave activity during physiological sleep and after administration of benzodiazepine hypnotics. Hum Neurobiol 6:203–210

    Google Scholar 

  • Achermann P, Borbély AA (1990) Simulation of human sleep: ultradian dynamics of EEG slow-wave activity. J Biol Rhythms 5:141–157

    Google Scholar 

  • Adam K (1980) Sleep as a restorative process and a theory to explain why. In: McConnell PS, Boer GJ, romijn HJ, Van de Poll NE (eds) Adaptive capabilities of the nervous system. Progress in brain research, vol 53, Elsevier, Amsterdam, pp 289–305

    Google Scholar 

  • Adam K, Oswald I (1989a) Can a rapidly-eliminated hypnotic cause daytime anxiety. Pharmacopsychiatry 22:115–119

    Google Scholar 

  • Adam K, Oswald I (1989b) Effects of repeated ritanserin on middle-aged poor sleepers. Psychopharmacology 99:219–221

    Google Scholar 

  • Adam K, Adamson L, Brezinova V, Hunter WM, Oswald I (1976) Nitrazepam: lastingly effective but trouble on withdrawal. Br Med J 1:1558–1560

    Google Scholar 

  • Akerstedt T (1988) Sleepiness as a consequence of shift work. Sleep 11:17–34

    Google Scholar 

  • Akerstedt T, Gillberg M (1981) The circadian variation of experimentally displaced sleep. Sleep 4:159–169

    Google Scholar 

  • Akerstedt T, Gillberg M (1986) Sleep duration and the power spectral density of the EEG. Electroencephalogr Clin Neurophysiol 64:119–122

    Google Scholar 

  • Arendt J, Aldhous M, Marks V (1986) Alleviation of jet-lag by melatonin: preliminary results of controlled double blind trial. Br Med J 292:1170

    Google Scholar 

  • Arendt J, Aldhous M, English J, Marks V, Arendt JH (1987) Some effects of jet-lag and their alleviation by melatonin. Ergonomics 30:1379–1393

    Google Scholar 

  • Balkin TJ, O'Donnell VM, Kamimori GH, Redmond DP, Belenky G (1989) Administration of triazolam prior to recovery sleep: effects on sleep architecture subsequent alertness and performance. Psychopharmacology 99:526–531

    Google Scholar 

  • Bausell RB (1986) A practical guide to conducting empirical research. Harper and Row, New York

    Google Scholar 

  • Belyavin A, Nicholson AN (1987) Rapid eye movement sleep in man: modulation by benzodiazepines. Neuropharmacology 26: 485–491

    Google Scholar 

  • Benoit O, Foret J (1988) Regulation circadienne des etats de veille et de sommeil. Neurophysiol Clin 18:403–431

    Google Scholar 

  • Billard M, Dissoubray C, Lubin S, Cadilhac J (1989) Short and long-term effects of modafinil in narcoleptic and in idiopathic CNS hypersomnic patients. In: Horne JA (ed) Sleep '88. Fischer, Stuttgart, pp 301–303

    Google Scholar 

  • Bonnet MH (1985) Effect of sleep disruption on sleep performance and mood. Sleep 8:11–19

    Google Scholar 

  • Borbély, AA (1982) A two-process model of sleep. Hum Neurobiol 1:195–204

    Google Scholar 

  • Borbély AA (1990) “Sleep substances”: criteria and physiological basis. In: Inoué S, Krueger JM (eds) Endogenous sleep factors. Bouma Text, Wassenaar, pp 31–38

    Google Scholar 

  • Borbély AA, Achermann P (1991) Ultradian dynamics of sleep after a single dose of benzodiazepine-hypnotics. Eur J Pharmacol 195:11–18

    Google Scholar 

  • Borbély AA, Tobler I (1989) Endogenous sleep-promoting substances and sleep regulation. Physiol Rev 69:605–670

    Google Scholar 

  • Borbély AA, Youmbi-Balderer G (1987) Effects of tryptophan on human sleep. In: Emser W, Kurtz D, Webb WB (eds) Sleep, aging and related disorders. Karger, Basel, pp 111–127

    Google Scholar 

  • Borbély AA, Baumann F, Brandeis D, Strauch I, Lehmann D (1981) Sleep-deprivation: effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol 51: 483–493

    Google Scholar 

  • Borbély AA, Mattmann P, Loepfe M, Fellmann I, Gerne M, Strauch I, Lehmann D (1983) A single dose of benzodiazepine hypnotics alters the sleep EEG in the following drug-free night. Eur J Pharmacol 89:157–161

    Google Scholar 

  • Borbély AA, Mattmann P, Loepfe M, Strauch I, Lehmann D (1985a) Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum Neurobiol 4:189–194

    Google Scholar 

  • Borbély AA, Balderer G, Trachsel L, Tobler I (1985b) Effect of midazolam and sleep deprivation on day-time sleep propensity. Arzneimittelforschung/Drug Res 35:1696–1699

    Google Scholar 

  • Borbély AA, Trachsel L, Tobler I (1988) Effect of ritanserin on sleep stages and sleep EEG in the rat. Eur J Pharmacol 156: 275–278

    Google Scholar 

  • Borbély AA, Achermann P, Trachsel L, Tobler I (1989) Sleep initiation and sleep intensity: interaction of homeostatic and circadian mechanisms. J Biol Rhythms 4:149–160

    Google Scholar 

  • Born J, Muth S, Fehm HL (1988) The significance of sleep onset and slow wave sleep for nocturnal release of growth hormone (GH) and cortisol. Psychoneuroendocrinology 13:233–243

    Google Scholar 

  • Brandenberger G, Follenius M, Simon C, Ehrhart J, Libert JP (1988) Nocturnal oscillations in plasma renin activity and REMNREM sleep cycles in humans: a common regulatory mechanism? Sleep 11:242–250

    Google Scholar 

  • Brunner DP, Dijk DJ, Tobler I, Borbély AA (1991) Effect of partial sleep deprivation on sleep stages and EEG power spectra: evidence for nonREM and REM sleep homeostasis. Electroencephalogr Clin Neurophysiol 75:492–499

    Google Scholar 

  • Brunner DP, Dijk DJ, Münch M, Borbély AA (1991) Effect of zolpidem on sleep and sleep EEG spectra in healthy young men. Psychopharmacology (in press)

  • Carskadon MA, Dement WI (1987) Daytime sleepiness: quantification of a behavioral state. Neurosci Biobehav Rev 11:307–417

    Google Scholar 

  • Church MW, March JD, Hibi S, Benson K, Cavness C, Feinberg I (1975) Changes in the frequency and amplitude of delta activity during sleep. Electroencephalogr Clin Neurophysiol 39:1–7

    Google Scholar 

  • Clodoré M, Foret J, Benoit O, Toitou Y, Aguirre A, Bouard G, Toitou G (1990) Psychophysiological effects of early morning bright light exposure in young adults. Psychoneuroendocrinology 15:193–205

    Google Scholar 

  • Consensus Conference: Drugs and Insomnia (1984) JAMA 251: 2410–2414

  • Copinschi G, Van Onderbergen A, L'Hermite-Balériaux M, Szyper M, Caufriez A, Bosson D, L'Hermite M, Robyn C, Turek FW, Van Cauter E (1990) Effects of the short-acting benzodiazepine triazolam taken at bedtime on circadian and sleep related hormonal profiles in normal men. Sleep 13:232–244

    Google Scholar 

  • Czeisler CA, Zimmerman JC, Ronda JM, Moore-Ede MC, Weitzman ED (1980) Timing of REM sleep is coupled to the circadian rhythm of body temperature in man. Sleep 2:329–346

    Google Scholar 

  • Czeisler CA, Allan JS, Strogatz SH, Ronda JM, Sanchez R, Rios CD, Freitag WO, Richardson GS, Kronauer RE (1986) Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. Science 233:667–671

    Google Scholar 

  • Czeisler CA, Kronauer RE, Allan JS, Duffy JF, Jewett ME, Brown EN, Ronda JM (1989) Bright light induction of strong: (type 0) resetting of the human circadian pacemaker. Science 244: 1328–1333

    Google Scholar 

  • Daan S, Beersma DGM, Borbély AA (1984) The timing of human sleep: recovery process gated by a circadian pacemaker. Am J Physiol 246:R161-R178

    Google Scholar 

  • Dijk DJ, Beersma DGM (1989) Effects of SWS deprivation on subsequent EEG power density and spontaneous sleep duration. Electoencephalogr Clin Neurophysiol 72:312–320

    Google Scholar 

  • Dijk DJ, Beersma DGM, Daan S (1987a) EEG power density during nap sleep: reflection of an hourglass measuring the duration of prior wakefulness. J Biol Rhythms 2:207–219

    Google Scholar 

  • Dijk DJ, Beersma DGM, Daan S, Bloem GM, Van den Hoofdakker RH (1987b) Quantitative analysis of the effects of slow wave sleep deprivation during the first 3 h of sleep on subsequent EEG power density. Eur Arch Psychiatry Neurol Sci 236:323–328

    Google Scholar 

  • Dijk DJ, Visscher CA, Bloem GM, Beersma DGM, Daan S (1987c) Reduction of human sleep duration after bright light exposure in the morning. Neurosci Lett 73:181–186

    Google Scholar 

  • Dijk DJ, Beersma DGM, Daan S, Van den Hoofdakker RH (1989) Effects of seganserin a 5HT2-antagonist and temazepam on human sleep stages and EEG power-spectra. Eur J Pharmacol 171:207–218

    Google Scholar 

  • Feinberg I (1974) Changes in sleep cycle patterns with age. J Psychiatr Res 10:283–306

    Google Scholar 

  • Feinberg I, Hibi S, Cavness C, March J (1974) Absence of REM rebound after barbiturate withdrawal. Science 185:534–535

    Google Scholar 

  • Feinberg I, Fein G, Walker JM, Price LJ, Floyd TC, March JD (1977) Flurazepam effects on slow-wave sleep: stage 4 suppressed but number of delta waves constant. Science 198:847–848

    Google Scholar 

  • Feinberg I, Fein G, Walker JM, Price LJ, Floyd TC, March JD (1979) Flurazepam effects on sleep EEG. Arch. Gen Psychiatry 36:95–102

    Google Scholar 

  • Folkard S, Akerstedt T (1987) Towards a model for the prediciton of alertness and/or fatigue on different sleep/wake schedules. In: Oginski A, Pokorski J, Rutenfranz J (eds) Contemporary advances in shiftwork research: theoretical and practical aspects in the late eighties. Medical Academy, Krakow, pp 231–240

    Google Scholar 

  • Folkard S, Akerstedt T (1988) Towards the prediction of alertness on abnormal sleep/wake schedules. In: Coblentz A (ed) Vigilance and performance in automatized systems. Kluwer, Dordrecht, pp 287–296

    Google Scholar 

  • Follenius M, Brandenberger G, Simon C, Schlienger JL (1988) REM sleep in humans begins during decreased secretory activity of the anterior pituitary. Sleep 11:546–555

    Google Scholar 

  • Gaillard JM, Blois R (1983) Effect of the benzodiazepine antagonist Ro 15-1788 on flunitrazepam-induced sleep changes. Br J Clin Pharmacol 15:529–536

    Google Scholar 

  • Gaillard JM, Blois R (1989) Differential effects of flunitrazepam on human sleep in combination with flumazenil. Sleep 12:120–132

    Google Scholar 

  • Gaillard JM, Schulz P, Tissot R (1973) Effects of three benzodiazepines (Nitrazepam, Flunitrazepam and Bromazepam) on sleep of normal subjects studied with an automatic sleep scoring system. Pharmacopsychiatry 6:207–217

    Google Scholar 

  • Gillin JC, Spinweber CL, Johnson LC (1989) Rebound insomnia: a critical review. J Clin Psychopharmacol 9:161–172

    Google Scholar 

  • Greenblatt DJ, Harmatz JS, Zinny MA, Shader RI (1987) Effect of gradual withdrawal on the rebound sleep disorder after discontinuation of triazolam. N Engl J Med 317:722–728

    Google Scholar 

  • Hayaishi O (1988) Sleep-wake regulation by prostaglandin D2 and E2. J Biol Chem 263:14593–14596

    Google Scholar 

  • Holsboer F, Bardeleben U von, Steiger A (1988) Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man. Neuroendocrinology 48:32–38

    Google Scholar 

  • Horne JA (1979) Restitution and human sleep: a critical review. Physiol Psychol 7:115–125

    Google Scholar 

  • Horne JA (1988) Why we sleep. The functions of sleep in humans and other mammals. Oxford University Press, Oxford

    Google Scholar 

  • Idzikowski C, Mills FJ, Glennard R (1985) 5-Hydroxytryptamine-2 antagonist increases human slow wave sleep. Brain Res 378: 164–168

    Google Scholar 

  • Idzikowski C, Cowen PJ, Nutt D, Mills FJ (1987) The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to L-tryptophan. Psychopharmacology 93:416–420

    Google Scholar 

  • Inoué S (1989) Biology of sleep substances. CRC Press, Boca Raton, Fla.

    Google Scholar 

  • James SP, Mendelson WB, Sack DA, Rosenthal NE, Wehr TA (1987) The effect of melatonin on normal sleep. Neuropsychopharmacology 1:41–44

    Google Scholar 

  • Janssen PFM (1987) Does ritanserin, a potent serotonin-S2 antagonist, restore energetic functions during the night? J R Soc Med 80:409–413

    Google Scholar 

  • Johnson LC, Spinweber CL (1981) Effect of a short-acting benzodiazepine on brain electrical activity during sleep. Electroencephalogr Clin Neurophysiol 52:89–97

    Google Scholar 

  • Johnson LC, Hanson K, Bickford RG (1976) Effect of flurazepam on sleep spindles and K-complexes. Electroencephalogr Clin Neurophysiol 40:67–77

    Google Scholar 

  • Johnson LC, Seales DM, Naitoh P, Church MW, Sinclair M (1979) The effects of flurazepam hydrochloride on brain electrical activity during sleep. Electroencephalogr Clin Neurophysiol 47: 309–321

    Google Scholar 

  • Johnson LC, Spinweber CL, Gomez SA, Matteson T (1990) Day-time sleepiness, performance, mood, nocturnal sleep: the effect of benzodiazepine and caffeine on their relationship. Sleep 13:121–135

    Google Scholar 

  • Johnson LC, Spinweber CL, Seidel WF, Dement WC (1983) Sleep spindle and delta changes during chronic use of a short-acting and a long-acting benzodiazepine hypnotic. Electroencephalogr Clin Neurophysiol 55:662–667

    Google Scholar 

  • Kales A, Scharf MG, Kales JD (1978) Rebound insomnia: a new clinical syndrome. Science 201:1039–1041

    Google Scholar 

  • Kales A, Soldatos CR, Bixler EO, Kales JD (1983a) Rebound insomnia and rebound anxiety: a review. Pharmacology 26:121–137

    Google Scholar 

  • Kales A, Soldatos CR, Bixler EO, Kales JD (1983b) Early morning insomnia with rapidly eliminated benzodiazepines. Science 220:95–97

    Google Scholar 

  • Mamelak M, Csima A, Price V (1990) The effects of a single night's dosing with triazolam on sleep the following night. J Clin Pharmacol 30:549–555

    Google Scholar 

  • Mattmann P, Loepfe M, Scheitlin T, Schmidlin D, Gerne M, Strauch I, Lehmann D, Borbély AA (1982) Day-time residual effects and motor activity after three benzodiazepine hypnotics. Arzneimittelforschung/Drug Res 32:461–465

    Google Scholar 

  • McCarley RW, Massaquoi S (1986) A limit cycle mathematical model of the REM sleep oscillator system. Am J Physiol 251: R1011-R1029

    Google Scholar 

  • Mesdger TA Jr (1990) Tryptophan-induced eosinophylia-myalgia syndrome. N Engl J Med 322:926–928

    Google Scholar 

  • Morgan K, Oswald I (1982) Anxiety caused by a short-life hypnotic. Br Med J 284:942

    Google Scholar 

  • Mrosovsky N, Salmon PA (1987) A behavioural method for accelerating re-entrainment of rhythms to new light-dark cycles. Nature 330:372–373

    Google Scholar 

  • Ogunremi OO, Adamson L, Brezinova V, Hunter WM, Maclean AW, Oswald I, Percy-Robb IW (1973) Two anti-anxiety drugs: a psychoneuroendocrine study. Br Med J 2:202–205

    Google Scholar 

  • Oswald I (1965) Some psychophysiological features of human sleep. Prog Brain Res 18:160–169

    Google Scholar 

  • Oswald I (1980) Sleep as a restorative process: human clues. In: McConnell PS, Boer GJ, Romijn HB, Van de Poll NE (eds) Adaptive capabilities of the nervous system. Progress in brain research, vol 53. Elsevier, Amsterdam, pp 279–288

    Google Scholar 

  • Oswald I, Priest RG (1965) Five weeks to escape the sleeping-pill habit. Br Med J 2:1093–1095

    Google Scholar 

  • Oswald I, Adam K, Spiegel R (1982) Human EEG slow-wave sleep increased by a serotonin antagonist. Electroencephalogr Clin Neurophysiol 54:583–586

    Google Scholar 

  • Patrick GTW, Gilbert JA (1896) On the effects of loss of sleep. Psychol Rev 3:469–483

    Google Scholar 

  • Petrie K, Conaglen JV, Thompson L, Chamberlain K (1989) Effect of melatonin on jet lag after long haul flights. Br Med J 298:705–707

    Google Scholar 

  • Rechtschaffen A, Kales AA (1968) Manual of standardized terminology techniques and scoring system for sleep stages of human subjects. U. S. Department of Health, Education and Welfare, Public Health Service, Bethesda, Md.

    Google Scholar 

  • Rhyner T, Mallet J, Borbély AA (1989) A molecular genetic approach to endogenous sleep promoting substances. In: Horne JA (Ed) Sleep '88. Fischer Stuttgart, p 111–113

    Google Scholar 

  • Rhyner T, Mallet J, Borbély AA (1990) Molecular cloning of forebrain mRNAs which are modulated by sleep-deprivation. Eur J Neurosci 2:1063–1073

    Google Scholar 

  • Roehrs T, Kribbs N, Zorick F, Roth T (1986) Hypnotic residual effects of benzodiazepines with repeated administration. Sleep 9:309–316

    Google Scholar 

  • Roehrs T, Timms V, Zwyghuizen-Doorenbos A, Roth T (1989) Sleep extension in sleepy and alert normals. Sleep 12:449–457

    Google Scholar 

  • Roehrs T, Vogel G, Roth T (1990) Rebound insomnia: its determinants and significance. Am J Med 88:39S-42S

    Google Scholar 

  • Saletu B, Frey R, Krupka M, Anderer P, Grunberger J, Barbanoj MJ (1989) Differential effects of the new central adrenergic agonist modafinil and d-amphetamine on sleep and early morning behaviour in elderlies. Arzneimittelforschung/Drug Res 39:1268–1273

    Google Scholar 

  • Sarrafzadeh A, Wirz-Justice A, Arendt J, English J (1990) Melatonin stabilises sleep onset in a blind man. In: Horne J (ed) Sleep '90. Pontenagel Press, Bochum, pp 51–54

    Google Scholar 

  • Schneider-Helmert D (1988) Why low-dose benzodiazepine-dependent insomniacs can't escape their sleeping pills. Acta Psychiatr Scand 78:706–711

    Google Scholar 

  • Schneider-Helmert D, Spinweber CL (1986) Evaluation of L-tryptophan for treatment of insomnia: a review. Psychopharmacology 89:1–7

    Google Scholar 

  • Sharpley AL, Solomon RA, Fernando AL, Roza Davis JM da, Cowen PJ (1990) Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans. Psychopharmacology 101:568–569

    Google Scholar 

  • Sims A, Prior P (1978) The pattern of mortality in severe neuroses. Br J Psychiatry 133:299–305

    Google Scholar 

  • Sinha AK, Smythe H, Zarcone VP, Barchas JD, Dement WC (1972) Human sleep-electroencephalogram: a damped oscillatory phenomenon. J Theor Biol 35:387–393

    Google Scholar 

  • Spiegel R (1981) Increased slow-wave sleep in man after several serotonin antagonists. In: Koella WP (Ed) Sleep '80. Karger, Basel, pp 275–278

    Google Scholar 

  • Steiger A, Herth T, Holsboer F (1987a) Sleep-electroencephalography and the secretion of cortisol and growth hormone in normal controls. Acta Endocrinol (Copenh) 116:36–42

    Google Scholar 

  • Steiger A, Holsboer F, Benkert O (1987b) Effects of brofaremine (CGP 11 305A) a short-acting reversible and selective inhibitor of MAO-A on sleep nocturnal penile tumescence and nocturnal hormonal secretion in three healthy volunteers. Psychopharmacology 92:110–114

    Google Scholar 

  • Torsvall L, Akerstedt T (1987) Sleepiness on the job: continuously measured EEG changes in train drivers. Electroencephalogr Clin Neurophysiol 66:502–511

    Google Scholar 

  • Torsvall L, Akerstedt T (1988) Extreme sleepiness: quantification of EOG and spectral EEG parameters. Int J Neurosci 38:435–441

    Google Scholar 

  • Trachsel L, Dijk DJ, Brunner D, Klene C, Borbély AA (1990) Effect of zopiclone and midazolam on sleep and EEG spectra in a phase-advanced sleep schedule. Neuropsychopharmacology 3:11–18

    Google Scholar 

  • Turek FW, Losee-Olson S (1986) A benzodiazepine used in the treatment of insomnia phase-shifts the mammalian circadian clock. Nature 321:167–168

    Google Scholar 

  • Van Reeth D, Turek FW (1989) Stimulated activity mediates phase shifts in the hamster circadian clock induced by dark pulses of benzodiazepines. Nature 339:49–51

    Google Scholar 

  • Wee BE, Turek FW (1989) Midzolam a short-acting benzodiazepine resets the circadian clock of the hamster. Pharmacol Biochem Behav 32:901–906

    Google Scholar 

  • Wever R, Polasek J, Wildgruber CM (1983) Bright light affects human circadian rhythms. Pflügers Arch 396:85–87

    Google Scholar 

  • Wingard DL, Berkman LF (1983) Mortality risk associated with sleeping patterns among adults. Sleep 6:102–107

    Google Scholar 

  • Wright NA, Belyavin A, Borland RG, Nicholson AN (1986) Modulation of delta activity by hypnotics in middle-aged subjects: studies with a benzodiazepine (flurazepam) and a cyclopyrrolone (zopiclone) Sleep 9:348–352

    Google Scholar 

  • Zulley J (1980) Distribution of REM sleep in entrained 24 hour and free-running sleep-wake cycle. Sleep 2:377–389

    Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacology, University of Zürich, Gloriastrasse 32, CH-8006, Zürich, Switzerland

    Aleander A. Borbély

  2. Laboratory of Clinical Stress Research, Karolinska Institute, S-10401, Stockholm, Sweden

    Torbjörn Åkerstedt

  3. URA CNRS 1159, Laboratoire d'Etude du Sommeil, Bâtiment Pharmacie Laboratoire, Hôpital de la Salpétrière, F-75651, Paris, France

    Odile Benoit

  4. Max-Planck Institut für Psychiatrie, D-8000, Munich, Germany

    Florian Holsboer

  5. The Birches, 41 St. Ronan's Terrace, EH44 6RB, Innerleithen, Peeblesshire, UK

    Ian Oswald

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  1. Aleander A. Borbély
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Borbély, A.A., Åkerstedt, T., Benoit, O. et al. Hypnotics and sleep physiology: A consensus repot. Eur Arch Psychiatry Clin Nuerosci 241, 13–21 (1991). https://doi.org/10.1007/BF02193749

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