Summary
Rats with extremely high and extremely low excitability of the central nervous system, determined by the intensity of the orientation reaction in new surrounding according to the techniques ofLát, showed significant differences in the effect of chlorpromazine, phenmetrazine, imipramine, and physostigmine on their exploratory activity and their avoidance reaction. Less excitable animals reacted by a greater excitation to an exciting drug, more excitable animals by a greater depression to a depressing drug. Chlorpromazine in the dose of 2 mg/kg evoked in less excitable rats paradoxal excitation.
Imipramine in the dose of 2 mg/kg increases only the rate of standing up, whereas phenmetrazine only the rate passing through a door from one chamber to another. The effect of imipramine especially in less excitable rats is an inverted picture of the effect of physostigmine.
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Soušková, M., Benešová, O. & Roth, Z. The effect of chlorpromazine, phenmetrazine, imipramine and physostigmine on the exploratory and conditioned avoidance reaction in rats with different excitability of the central nervous system. Psychopharmacologia 5, 447–456 (1964). https://doi.org/10.1007/BF02193482
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DOI: https://doi.org/10.1007/BF02193482