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CSF levels of diazepam-binding inhibitor correlate with REM latency in schizophrenia, a pilot study

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Abstract

CSF diazepam-binding inhibitor-like immuno-reactivity (DBI-LI) and polysomnography were studied in 28 drug-free male schizophrenic (DSM-III-R) patients. They underwent a three-night polysomnography evaluation and a lumbar puncture. CSF DBI-LI correlated positively with REM latency, the REM latency/2d nonREM period ratio and stage-4% sleep, and negatively with stage-1% sleep. CSF DBI-LI did not correlate significantly with duration of sleep or sleep latency. CSF DBI-LI during haloperidol treatment did not correlate significantly with sleep EEG measures. The results of this first study of the relationship between endogenous DBI and sleep in humans suggest that physiological effects of DBI other than interactions with the BZD/GABAA receptor complex may explain its positive effects on sleep. However, the absence of similar sleep data in normal subjects precludes us from establishing a specific relationship between DBI and sleep in schizophrenia.

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Authors and Affiliations

  1. Highland Drive Veterans Affairs Medical Center, 15206, Pittsburgh, PA

    Thomas Neylan, Mary E. Kelley, John Gurklis, Mark W. Gilbertson & Jeffrey L. Peters

  2. Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA

    Daniel P. van Kammen, Thomas Neylan, John Gurklis & Jeffrey L. Peters

  3. FIDIA-Georgetown Institute for the Neurosciences, Washington DC

    Alessandro Guidotti, Patrizia Guaneri & Erminio Costa

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  1. Daniel P. van Kammen
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  2. Alessandro Guidotti
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  3. Thomas Neylan
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  4. Patrizia Guaneri
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  5. Mary E. Kelley
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  9. Erminio Costa
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van Kammen, D.P., Guidotti, A., Neylan, T. et al. CSF levels of diazepam-binding inhibitor correlate with REM latency in schizophrenia, a pilot study. Eur Arch Psychiatry Clin Nuerosci 244, 216–222 (1994). https://doi.org/10.1007/BF02190401

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