Abstract
Morphometry on transmission electron micrographs of the hemidesmosomal width was related to the length of the basal plasmalemma in corneal epithelium biopsy specimens. The basal plasmalemma length occupied by hemidesmosomes showed a mean fraction of 0.227 in eight patients undergoing cataract extraction or vitrectomy for diabetic proliferative vitreoretinopathy. In seven non-diabetic control patients of comparable age and sex undergoing cataract or pterygium surgery, 0.412 of the basal plasmalemma was covered by hemidesmosomes. A reduction in hemidesmosomes (P < 0.001) may contribute to a weakness in the adhesion of diabetic corneal epithelium to the underlying stroma.
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Alvarado J, Murphy C, Juster R (1983) Age-related changes in the basement membrane of the human corneal epithelium. Invest Ophthalmol Vis Sci 24:1015–1028
Azar DT, Gibson IK (1987) Repair of the basement membrane adhesion of the corneal epithelium following keratectomy wounds in diabetic rabbits. Invest Ophthalmol Vis Sci [Suppl] 28:53
Buck RC (1982) Hemidesmosomes of normal and regenerating mouse corneal epithelium. Virchows Arch [Cell Pathol] 41:1–16
Gibson IK, Grill SM, Spurr SJ, Brennan SJ (1983) Hemidesmosome formation in vitro. J Cell Biol 97:849–857
Gibson IK, Spurr SJ, Kimerer LM, Tisdale AS (1985) Anchoring fibrils of the cornea: comparisons between normal and diabetic human and rabbit. Invest Ophthalmol Vis Sci [Suppl] 26:93
Gibson IK, Spurr-Marchand SJ, Tisdale AS (1987) Anchoring fibrils form a complex network in human and rabbit cornea. Invest Ophthalmol Vis Sci 28:212–220
Hyndiuk RA, Kazarian EL, Schultz RO, Seideman S (1977) Neurotrophic corneal ulcers in diabetes mellitus. Arch Ophthalmol 95:2193–2196
Jakus MA (1962) Further observations on the fine structure of the cornea. Invest Ophthalmol 1:202–225
Keene DR, Sakai LY, Lunstrum GP, Morris NP, Burgeson RE (1987) Type VII collagen forms an extended network of anchoring fibrils. J Cell Biol 104:611–621
Kenyon KR, Wafai Z, Michels RC, Conway B, Tolentino F (1978) Corneal basement membrane abnormality in diabetes mellitus. Invest Ophthalmol Vis Sci [Suppl] 17: 245
Perry HD, Foulks GN, Thoft RA, Tolentino FI (1978) Corneal complications following closed vitrectomy through the pars plana. Arch Ophthalmol 96:1401
Schimmelpfennig B, Beuerman R (1982) A technique for controlled sensory denervation of the rabbit cornea. Graefe's Arch Clin Exp Ophthalmol 218:287–293
Taylor HR, Kimsey RA (1981) Corneal epithelial basement membrane changes in diabetes. Invest Ophthalmol Vis Sci 20:548–553
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This work was supported by the Swiss National Science Foundation, grants 3.930.0.82 and 3.883.0.85
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Tabatabay, C.A., Bumbacher, M., Baumgartner, B. et al. Reduced number of hemidesmosomes in the corneal epithelium of diabetics with proliferative vitreoretinopathy. Graefe's Arch Clin Exp Ophthalmol 226, 389–392 (1988). https://doi.org/10.1007/BF02172973
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DOI: https://doi.org/10.1007/BF02172973