Abstract
BG-104 is a compound of Chinese herbs which were treated with infrared ray-heating and brewed with microorganisms resulting in activation of actual principles contained in the herbs, and its effectiveness has been reported on various inflammatory disorders such as Behcet's disease, rheumatoid arthritis, bacterial infections and so on. In addition, it is noted as an effective agent to retard cancer progress. This report shows a superoxide scavenging activity of BG-104 using an ESR spin trapping method. For the measurement of superoxide scavenging activity, recombinant human superoxide dismutase is used as a standard. Superoxide scavenging activity of BG-104 increases in a dose-dependent manner and activity is significantly augmented by its sonication.
Similar content being viewed by others
References
Niwa Y, Miyachi Y. Antioxidant action of natural health products and Chinese herbs. Inflammation 1986; 10: 79–91.
Naim M, Gestetner M, Bondi A, Birk Y. Antioxidative and antihemolytic activities of soybean isoflavonoids. J Agric Food Chem 1976; 24: 1174–7.
Chien YW. Novel drug delivery systems fundamentals, developmental concepts, biomedical assessments. In: Drugs and the Pharm. Sci., Vol. 14. New York & Basel: Marcel Dekker Inc, 1983.
Niwa Y, Kanoh T, Kasama T, Negishi M. Activation of antioxidant activity in natural medicinal products by heating, brewing and lipophilization. A new drug delivery system. Drugs Exptl Clin Res 1988; 14: 361–72.
Niwa Y. Action mechanism of Chinese herbs, BG-102, 103 & 104 with special reference to their effects on membrane phospholipid enzyme activities of human leukocytes and oxygen radical generated. Jpn J Inflammation (in Japanese) 1987; 7: 367–75.
Niwa Y. Effect of cancer retardant, BG-104 on the various kinds of malignancies. In: Proceedings of the Japanese Cancer Association, 47th Annual Meeting, September, 1988, Tokyo.
Niwa Y. Investigation of the drug delivery system (DDS) in natural medicinal or health products - clinical effectiveness and inhibitory effect of lipid peroxidation of SOD-like health products and cancer retardant effect of natural product BG-104. Pharm Tech Janan (in Japanese) 1987; 3: 1067–81.
Hiramatsu M, Kohno M. Determination of superoxide dismutase activity by electron spin resonance spectrometry using the spin trap method. JEOL NEWS Vol. 23A No. 1 7–9, 1987.
Niwa Y, Motoyama S. Bioavailability of SOD (superoxide dismutase) and crude drug. J Jpn Assoc Pharmaceutist (in Japanese) 1987; 39: 1097–119.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pronai, L., Arimori, S. & Nakazawa, H. Superoxide scavenging activity of BG-104 before and after sonication-determined by ESR spin trapping method. Biotherapy 2, 63–68 (1990). https://doi.org/10.1007/BF02172077
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02172077