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Fusion of macrophages on lens implants resulting in the formation of giant cells

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Abstract

Giant cells on lens implants are understood to be a sign of chronic irritation. These multinucleated cells develop from macrophages by fusion and they disappear in successful cases along with the free-moving macrophages, when the fixed fibroblast-like cells and the proteinaceous capsule have succeeded in creating a continuous and effective separation on the surface of a lens implant. Details about the stages in the development of giant cells on lens implants as well as their significance as typical representatives of chronic granulomatous inflammation are discussed.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA

    J. Reimer Wolter

  2. Department of Pathology, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA

    J. Reimer Wolter

Authors
  1. J. Reimer Wolter
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Supported by The Research to Prevent Blindness, Inc. New York, USA

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Wolter, J.R. Fusion of macrophages on lens implants resulting in the formation of giant cells. Graefe's Arch Clin Exp Ophthalmol 221, 1–7 (1983). https://doi.org/10.1007/BF02171723

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  • DOI: https://doi.org/10.1007/BF02171723

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