Abstract
High biocompatibility is one of the main features expected of an intraocular lens (IOL) implant. In terms of anatomical position an implant is close to, or in contact with, uveal tissue and the capsule. Therefore, uveal reactions of the eye must be distinguished from capsular reactions. As both reactions are influenced by the implant, one should rightly address the subjects of uveal biocompatibility and capsular biocompatibility separately. The iris, the ciliary body, and the choroid are composed of vascularized tissue and are close to the implant. In cases of iridolenticular synechiae or sulcus position of the IOL, portions of the lens come into direct contact with uveal tissue. Changes in blood-aqueous barrier due to surgical trauma and the implanted foreign body cause leakage of proteins and macrophages from blood.
The main parameters of capsular biocompatibility are lens epithelial cell (LEC) outgrowth, anterior capsule opacification (ACO), posterior capsule opacification (PCO), and contraction of the capsule; IOLs that perform well in these respects may be said to possess high capsular biocompatibility.
The foreign-body cell reaction is the most important parameter of uveal biocompatibility; IOLs causing a very mild foreign-body reaction could be rightly referred to as IOLs with uveal biocompatibility. Implants with high uveal biocompatibility are especially suitable for eyes with a compromised blood-aqueous barrier (BAB).
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References
Scales J (1953) Discussion on metals and synthetic materials in relation to soft tissues: tissue reaction to synthetic materials. Proc R Soc Med 46:647
Becker EL, Landau SI (1986) International dictionary of medicine and biology, vol 1. Churchill Livingstone, New York/Edinburgh/London/Melbourne
Amon M, Menapace R (1994) In vivo documentation of cellular reactions on lens surfaces for assessing the biocompatibility of different intraocular implants. Eye 8 (Pt 6):649–656
Wolter JR (1983) Morphology of the capsule-like portion of the reactive membranes on intraocular lens implants. Graefes Arch Clin Exp Ophthalmol 220:58–65
Wolter JR (1982) Cell life on the surface of lens implants. Graefes Arch Clin Exp Ophthalmol 218:244–249
Amon M (2001) Uveal and capsular Biocompatibility of Intraocular Implants. J Cataract Refract Surg 27(2):178–179
Miyake K, Asakura M, Kobayashi H (1984) Effect of intraocular lens fixation on the blood-aqueous barrier. Am J Ophthalmol 98:451–453
Spalton DJ, Shah SM, Kerr Muir MG (1993) Specular microscopy of the anterior intraocular lens surface. Eye 7:707–710
Nishi O (1999) Posterior capsule opacification. Experimental investigations. J Cataract Refract Surg 25:106–117
Apple D, Solomon K, Tetz M (1991) Posterior capsule opacification. Surv Ophthalmol 37:73–116
Schauersberger J, Kruger A, Schild G, Amon M (2001) Lens epithelial cell outgrowth on three different intraocular lenses. J Cataract Refract Surg 27(6):850–854
Schild G, Schauersberger J, Amon M, Abela-Formanek C, Kruger A (2005) Lens epithelial cell ongrowth: comparison of 6 types of hydrophilic intraocular lens models. J Cataract Refract Surg 31(12):2375–2378
Wolter JR (1993) Continuous sheet of lens epithelium on an intraocular lens: pathological confirmation of specular microscope. J Cataract Refract Surg 19:789–792
Linnola R, Werner L, Pandey S, Escobar-Gomez M, Znoiko S, Apple D (2000) Adhesion of fibronectin, vitronectin, laminin, and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes. Part 1: histological sections. J Cataract Refract Surg 26:1792–1806
Wenzel M, Reim M, Heinze M, Böcking A (1988) Cellular invasion on the surface of intraocular lenses. In vivo cytological observations following lens implantation. Graefes Arch Clin Exp Ophthalmol 226:449–454
Versura P, Caramazza R (1992) Ultrastructure of cells cultured onto various intraocular lens materials. J Cataract Refract Surg 18:58–64
Kruger A, Schauersberger J, Abela C, Schild G, Amon M (2000) Two year results: sharp versus rounded optic edges on silicone lenses. J Cataract Refract Surg 26:566–570
Abela-Formanek C, Amon M, Schauersberger J, Kruger A, Nepp J, Schild G (2002) Results of hydrophilic acrylic, hydrophobic acrylic and silicone intraocular lenses in uveitic eyes with cataract: comparison to a control group. J Cataract Refract Surg 28(7):1141–1152
Ravalico G, Baccara F, Lovisato A, Tognetto D (1997) Postoperative cellular reaction on various intraocular lens materials. Ophthalmology 104:1084–1091
Amon M (1992) The importance of in-vivo documentation of cellular reactions on lens-surfaces for assessing the biocompatibility of different intraocular implants. Spektrum der Augenheilkunde 6(7): Suppl 7
Abela-Formanek C, Amon M, Kahraman G, Schauersberger J, Dunavoelgyi R (2011) Biocompatibility of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses in eyes with uveitis having cataract surgery: long-term follow-up. J Cataract Refract Surg 37(1):104–112. doi:10.1016/j.jcrs.2010.07.038
Richter-Mueksch S, Kahraman G, Amon M, Schild-Burggasser G, Schauersberger J, Abela-Formanek C (2007) Uveal and capsular biocompatibility after implantation of sharp-edged hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses in eyes with pseudoexfoliation syndrome. J Cataract Refract Surg 33(8):1414–1418
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Amon, M., Kahraman, G. (2014). Capsular and Uveal Biocompatibility of Different IOLs in Eyes With and Without Associated Conditions. In: Saika, S., Werner, L., Lovicu, F. (eds) Lens Epithelium and Posterior Capsular Opacification. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54300-8_18
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DOI: https://doi.org/10.1007/978-4-431-54300-8_18
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