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Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/

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Abstract

Platinum and eleven other trace elements were determined by radiochemical neutron activation analysis in tissues of healthy rats and dogs treated with the anti-cancer drug carboplatin. In rats the levels of the trace elements were not much influenced; in the kidney only the Co and the Sb levels were decreased and in the liver only the Mo level was increased. A parallel tendency in the Co and Mo metabolism was seen in dogs. Carboplatin treatment tends to reduce the Cd, Co and Fe levels in metabolic active organs, kidney, liver, spleen and/or pancreas of the dog.

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Authors and Affiliations

  1. Interuniversity Reactor Institute, Mekelweg 15, 2629 JB, Delft, The Netherlands

    P. S. Tjioe & J. J. Kroon

  2. Radiobiological Institute TNO, P.O. Box 5815, 2280 HV, Rijswijk, The Netherlands

    P. Lelieveld

  3. Academic Hospital, Free University, DeBoelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    W. J. F. Van der Vijgh

Authors
  1. P. S. Tjioe
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  2. J. J. Kroon
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  3. P. Lelieveld
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  4. W. J. F. Van der Vijgh
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Tjioe, P.S., Kroon, J.J., Lelieveld, P. et al. Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/. Journal of Radioanalytical and Nuclear Chemistry Letters 104, 103–113 (1986). https://doi.org/10.1007/BF02166925

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  • DOI: https://doi.org/10.1007/BF02166925

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