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Automated preparation of carbon-11 ethanol and carbon-11 butanol for human studies using positron emission tomography

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Abstract

An automated continuous flow process has been developed for the synthesis of11C-ethanol and11C-butanol. These alcohols were synthesized via the same route. The reaction of11CO2 with methylmagnesium bromide or with n-propylmagnesium chloride, followed by a lithium aluminum hydride reduction and hydrolysis produced respectively11C-ethanol and11C-butanol. Preparation can be completed in 25 min. In each case the radiochemical purity, as determined by high pressure liquid chromatography /HPLC/ was greater than 98%. Biological quality control shows that the products are suitable for human use. The process has been completely automated to limit radiation exposure to personnel, reduce preparation time, and increase reproducibility.

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Authors and Affiliations

  1. Centre de Recherches du Cyclotron /C.R.C./, Université de Liege, Sart-Tilman, B-30, B-4000, Liège, Belgique

    J. M. Peters, L. Quaglia, M. C. Pardon, J. L. Piette, R. Cantineau, Ch. De Landsheere & P. Rigo

  2. Institut Malvoz, Liège, Belgique

    G. Del Fiore

  3. C.E.N., Alger, Algérie

    F. Boudjelida

Authors
  1. G. Del Fiore
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  2. J. M. Peters
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  3. L. Quaglia
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  4. F. Boudjelida
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  5. M. C. Pardon
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  6. J. L. Piette
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  7. R. Cantineau
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  8. Ch. De Landsheere
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  9. P. Rigo
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Del Fiore, G., Peters, J.M., Quaglia, L. et al. Automated preparation of carbon-11 ethanol and carbon-11 butanol for human studies using positron emission tomography. Journal of Radioanalytical and Nuclear Chemistry Letters 104, 301–315 (1986). https://doi.org/10.1007/BF02163212

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  • DOI: https://doi.org/10.1007/BF02163212

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