Abstract
The long-term effect of timolol maleate on lacrimal secretion was tested by investigating the concentration of lysozyme and albumin in tears before the start of treatment and after different follow-up periods. A total of 25 patients (45 eyes) were treated with 0.25% or 0.5% timolol as the only antiglaucomatous therapy over a 7.6-month mean observation period (2–13 months). No significant change was found either in the lysozyme or in the albumin concentration.
Zusammenfassung
Die Langzeitwirkung von Timolol-Maleat auf die Funktion der Tränendrüse wurde mittels Bestimmung von Lysozym und Albumin in der Tränenflüssigkeit vor und nach verschiedenen Behandlungszeiträumen untersucht. Die Studie umfaßte 25 Patienten (45 Augen), welche 0,25% oder 0,5% Timolol über eine durchschnittliche Dauer von 7,6 Monaten (2–13 Monate) erhielten. Eine signifikante Anderung der Konzentration konnte weder bei Lysozym noch bei Albumin festgestellt werden.
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References
Amos HE, Brigden WD, McKerron RA (1975) Untoward effects associated with practolol: demonstration of antibody binding to epithelial tissue. Br Med J 1: 598–601
Ashburn FS, Jr, Gillespie JE, Kass MA, Becker B (1980) Timolol plus maximum tolerated antiglaucoma therapy: a one-year follow up study. Surv Ophthalmol 23: 389–394
Bischoff P (1978) Erfahrungen mit Timolol in der Glaukomtherapie. Klin Monatsbl Augenheilk 173: 202–207
Bonomi L, Zavarise G, Noya E, Michieletto S (1980) Effects of timolol maleate on tear flow in human eyes. Albrecht von Graefes Arch Klin Exp Ophthalmol 213: 19–22
Covey W, Perillie P, Finck SC (1971) The origin of tear lysozyme. Proc Soc Exp Biol Med 137: 1362–1363
Gillette TE, Allansmith MR, Greiner JV, Janusz M (1980) Histologic and immunohistologic comparison of main and accessory lacrimal tissue. Am J Ophthalmol 89: 724–730
Hass I, Drance SM (1979) Topical timolol in open-angle glaucoma. Can J Ophthalmol 14: 235–238
Kosman ME (1979) Timolol in the treatment of open angle glaucoma. J Am Med Assoc 241: 2301–2303
Laurell CB (1966) Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 15: 45–51
Luger T, Kokoschka EM, Sagaster P, Miksche M (1979) Serum lysozyme levels in patients with solid tumors. Oncology 36: 15–18
McEwen WK, Kimura SW (1955) Filter-Paper Electrophoresis of tears. Am J Ophthalmol 33: 200–202
McMahon CD, Shaffer RN, Hoskins HD, Jr, Hetherington J, Jr (1979) Adverse effects experienced by patients taking timolol. Am J Ophthalmol 88: 736–738
Meyer K (1948) Mucopolysaccharides and Mucoids of ocular tissues and their enzymatic hydrolysis. In Sorsby A (ed): Modern Trends in Ophthalmology, London: Butterworth & Co, Ltd, vo 2 : 71–78
Nielsen NV, Eriksen JS (1979) Timolol in maintenance treatment of ocular hypertension and glaucoma. Acta Ophthalmol 57: 1070–1077
Regan EF (1950) The lysozyme content of tears. Am J Ophthalmol 33: 600–605
Strempel I (1979) Timolol Langzeitergebnisse, Belastungstest und Frühmessungen. Klin Monatsbl Augenheilk 175: 619–626
Thygeson P, Kimura SJ (1963) Chronic conjunctivitis. Trans Am Acad Ophthalmol Otolaryng 67: 494–517
van Bijsterveld OP (1969) Diagnostic tests in the sicca syndrome. Arch Ophthalmol 82: 10–14
van Buskirk EM (1980) Adverse reactions from timolol administration. Ophthalmology 87: 447–450
Wilson RP, Spaeth GL, Poryzees E (1980) The place of timolol in the practice of ophthalmology. Ophthalmology 87: 451–454
Wright P (1975) Untoward effects associated with practolol administration: oculomucocutaneous syndrome. Br Med J 1: 595–597
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Strasser, G., Grabner, G. The influence of long-term treatment with timolol on human tear lysozyme and albumin content. Graefe's Arch Clin Exp Ophthalmol 218, 93–95 (1982). https://doi.org/10.1007/BF02153718
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DOI: https://doi.org/10.1007/BF02153718