Skip to main content
SpringerLink
Log in

Effect of bromhexine, ambroxol, and placebo on clinical and histopathological changes in “Sjögren” mice

  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Hybrids of New Zealand black and New Zealand white mice were used in an animal model for Sjögren's syndrome. The animals were treated with bromhexine (Bisolvon), ambroxol (Mucosolvan), or placebo from their 20th week of life for 10–17 weeks. The parotic glands were examined in a masked fashion by light and transmission electron microscopy after treatment. Significant inhibition of pathological changes in the parotic glands was observed by both methods in hybrids receiving 60 mg/kg bromhexine. Other types of treatment had no effect. In addition, the animals receiving the high dosage of bromhexine had a significantly higher survival rate than other hybrids.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Avisar R, Savir H, Machtey I, Ovaknin L, Shaked P, Menache R, Allatouf D (1981) Clinical trial of bromhexine in Sjögren's syndrome. Ann Ophthalmol 13:971–973

    PubMed  Google Scholar 

  • Dixon FJ (1982) Mucin lupus — an overview. Arth Rheum 25:721–725

    Google Scholar 

  • Frost-Larsen K, Isager H, Manthorpe R (1978) Sjögren's syndrome treated with bromhexine: a randomised clinical study. Br Med J 1:1579–1581

    PubMed  Google Scholar 

  • Howie JB, Helyer BJ (1968) The immunology and pathology of NZB mice. Adv Immunol 9:215–266

    PubMed  Google Scholar 

  • Kessler HS (1968) A laboratory model for Sjögren's syndrome. Am J Pathol 52: 671–685

    PubMed  Google Scholar 

  • Manthorpe R, Frost-Larsen K, Isager H, Prause JU (1981) Sjögren's syndrome. A review with emphasis on immunological features. Allergy 36:139–153

    PubMed  Google Scholar 

  • Mellors RC (1966) Autoimmune and immunoproliferative disease of NZB/Bl mice and hybrids. Int Rev Exp Pathol 5:217–252

    PubMed  Google Scholar 

  • Milich DR, Gershwin ME (1980) The pathogenesis of autoimmunity in New Zealand mice. Semin Arthritis Rheum 10:111–147

    PubMed  Google Scholar 

  • Nahir AM, Scharf Y, Ben-Aryeh H, Szargel R, Gutman D, Zonis S, Scharf J (1981) Effect of prolonged bromhexine therapy on Sjögren's syndrome. Isr J Med Sci 17:403–406

    PubMed  Google Scholar 

  • Prause JU, Frost-Larsen K, Høj L, Isager H, Mathorpe R (1984) Lacrimal and salivary secretion in Sjögren's syndrome. The effect of systemic treatment with bromhexine. Acta Ophthalmol 62:489–497

    Google Scholar 

  • Rossmann H (1974) Behandlung verminderter Tränensekretion mit Bromhexine-Augentropfen. Dtsch Med Wochenschr 99: 408–410

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eye Pathology Institute, University of Copenhagen, Frederik V's Vej 11, DK-2100, Copenhagen Ø, Denmark

    J. U. Prause

  2. Department of Internal Medicine, Division of Rheumatology, Malmö General Hospital, University of Malmö/Lund, Malmö, Sweden

    O. A. Jensen & R. Manthorpe

Authors
  1. J. U. Prause
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. A. Jensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Manthorpe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Prause, J.U., Jensen, O.A. & Manthorpe, R. Effect of bromhexine, ambroxol, and placebo on clinical and histopathological changes in “Sjögren” mice. Graefe's Arch Clin Exp Ophthalmol 223, 259–264 (1985). https://doi.org/10.1007/BF02153656

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02153656

Keywords

Search

Navigation