Skip to main content
SpringerLink
Log in

The action of calcium and thrombin on isolated 5-hydroxytryptamine organelles of blood platelets

  • Specialia
  • Chimica. Biochimica. Biophysica
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

In isolierten 5-Hydroxytryptamin-(5HT)-Organellen aus Blutplättchen von Kaninchen, im Gegensatz zu intakten Plättchen, bewirkt Thrombin keine wesentliche Freisetzung von 5HT und Adenosin-Triphosphat (ATP). Anderseits erzeugen geringe Konzentrationen von Kalzium starke Verminderung von 5HT und ATP in den Organellen, hingegen nicht in intakten Plättchen. Nach elektronenmikroskopischen Befunden verursacht Kalzium hochgradige morphologische Veränderungen der isolierten 5HT-Organellen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. K. Grette, Scand. J. clin. Lab. Invest.11, 50 (1959).

    Article  CAS  Google Scholar 

  2. M. B. Zucker, inProgress in Hematology (Ed.L. M. Tocantinis; Grune and Stratton, New York 1959), vol. 2, p. 206.

    Google Scholar 

  3. J. R. Gainter, D. P. Jackson andE. W. Maynert, Bull. Johns Hopkins Hosp.111, 185 (1962).

    Google Scholar 

  4. F. Markwardt andW. Barthel, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.249, 176 (1964).

    Article  CAS  Google Scholar 

  5. M. Da Prada, G. Bartholini andA. Pletscher, Experientia21, 135 (1965).

    Article  Google Scholar 

  6. M. Paasonen, J. Pharm. Pharmac.17, 681 (1965).

    Article  CAS  Google Scholar 

  7. F. Markwardt, W. Barthel, A. Hoffmann andE. Wittwer, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.251, 255 (1965).

    CAS  Google Scholar 

  8. J. P. Tranzer, D. Da Prada andA. Pletscher, Nature213, 1574 (1966).

    Article  Google Scholar 

  9. J. P. Tranzer, M. Da Prada andA. Pletscher, inAdvances in Pharmacology (Pergamon, New York 1968), vol. 6, p. 125.

    Google Scholar 

  10. M. Da Prada, A. Pletscher, J. P. Tranzer andH. Knuchel, Nature216, 1315 (1967).

    Article  Google Scholar 

  11. G. Bartholini, A. Pletscher andK. F. Gey, Experientia17, 541 (1961).

    Article  CAS  Google Scholar 

  12. M. Da Prada andA. Pletscher, Br. J. Pharmac., in press.

  13. D. F. Bogdanski, A. Pletscher, B. B. Brodie andS. Uden-Friend, J. Pharmac. exp. Ther.117, 82 (1956).

    CAS  Google Scholar 

  14. H. Holmsen, I. Holmsen andA. Bernhardsen, Analyt. Biochem.17, 456 (1966).

    Article  CAS  Google Scholar 

  15. G. Bartholini andA. Pletscher, Experientia20, 376 (1964).

    Article  CAS  Google Scholar 

  16. A. R. Baumgartner, J. P. Tranzer andA. Studer, Thromb. Diath. haemorrh.18, 592 (1967).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Forschungsabteilung der F. Hoffmann-La Roche & Co. AG, Basel, Switzerland

    A. Pletscher, M. Da Prada & J. P. Tranzer

Authors
  1. A. Pletscher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Da Prada
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. P. Tranzer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pletscher, A., Da Prada, M. & Tranzer, J.P. The action of calcium and thrombin on isolated 5-hydroxytryptamine organelles of blood platelets. Experientia 24, 1202–1203 (1968). https://doi.org/10.1007/BF02146619

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02146619

Keywords

Search

Navigation