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The neurosecretory system of the octopus vena cava: A neurohemal organ

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Summary

Endings of about two million small neurones form a voluminous neuropil inside the vena cava of cephalopods, in direct contact with the blood. These nerve endings are filled with masses of typical neurosecretory granules. By immunocytochemistry we could distinguish three different populations of secretory endings in the vena cava neuropil ofOctopus vulgaris: 1) a population of endings which were immunoreactive with antibodies against the pentapeptide proctolin; 2) a population with oxytocin/vasopressin- and neurophysin-like immunoreactivity; 3) a population immunoreactive with antibodies which were raised against the molluscan cardioexcitatory peptide Phe-Met-Arg-Phe-amide, against α-melanotropin, and against atriopeptin. Extracts of the octopus vena cava stimulated amplitude and frequency of the isolated octopus heart preparation. Similar effects were exerted by peptides with the C-terminal structure-Arg-Phe-amide. Recently, we could isolate and identify in vena cava extracts four peptides; Phe-Met-Arg-Phe-amide, Phe-Leu-Arg-Phe-amide, Ala-Phe-Leu-Arg-Phe-amide and Thr-Phe-Leu-Arg-Phe-amide. Other peptides have not yet been identified. The fact that the peptides against which the immunoreactive antibodies were raised affected, in different organisms, blood volume, blood pressure, renal function and heart contraction suggests that one of the main functions of the neurosecretory system of the vena cava is a hormonal control of circulation.

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Authors and Affiliations

  1. Sektion Elektronenmikroskopie, Universität Ulm, D-7900, Ulm, Germany

    R. Martin & K. H. Voigt

  2. Klinikum Steglitz, Institut für Klinische Pharmakologie, Hindenburgdamm 30, D-1000, Berlin 45, Germany

    R. Martin & K. H. Voigt

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Martin, R., Voigt, K.H. The neurosecretory system of the octopus vena cava: A neurohemal organ. Experientia 43, 537–543 (1987). https://doi.org/10.1007/BF02143582

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