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The X-ray analysis of the structure of rifamycin Y

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  • Chimica. Biochimica
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Riassunto

La struttura cristallina dellap-iodio anilide della rifamicina Y è stata determinata con metodi tridimensionali a temperatura ambiente. La cella elementare monoclina, gruppo spaziale P21, ha i parametria = 9,49,b = 18,96,c = 15,30 Å,β = 90°48′, e contiene due molecole.

La costituzione e la configurazione della rifamicina Y, C39H47NO15, risultano quindi determinate attraverso lo studio cristallografico della suap-iodio anilide. Anche molte informazioni sulla configurazione della rifamicina Y possono essere tratte dalla configurazione allo stato solido di questo suo derivato.

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References

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  11. A. McL. Mathienson, Tetrahedron Lett. No. 46, 4137 (1965). We take this opportunity to modify a conformational detail of the structure of rifamycin B as published in 1964; the ‘labels’ C(36) and O(8) should be interchanged in the Table of atomic coordinates and in the Figures 2, 3 and 4 of our 1964 paper in Experientia9, thus obtaining the above mentioned preferred conformation of the ester group also in the case of rifamycin B. This is the only important change in the structure of thep-iodoanilide derivative of rifamycin B found during the final refinement now completed and to be published elsewhere.

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Authors and Affiliations

  1. Centro di Studio per la Strutturistica Chimica (CNR), Istituto di Chimica Farmaceutica e Tossicologica della Università degli Studi, Roma, Italy

    M. Brufani, W. Fedeli, G. Giacomello & A. Vaciago

Authors
  1. M. Brufani
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  2. W. Fedeli
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  3. G. Giacomello
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  4. A. Vaciago
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Additional information

A brief preliminary report on this structure was read at a meeting of the Accademia Nazionale dei Lincei, Rome, on 12th March 19662.

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Brufani, M., Fedeli, W., Giacomello, G. et al. The X-ray analysis of the structure of rifamycin Y. Experientia 23, 508–512 (1967). https://doi.org/10.1007/BF02137935

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