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Ovarian hyperstimulation due to long-term pulsatile intravenous GnRH treatment

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Summary

Pulsatile long-term gonadotropin releasing hormone (GnRH) therapy with an average dosage of 8 μg/pulse i.v. in intervals of 90 min induced in a patient with hypothalamic amenorrhea the development of multiple ovarian cysts as visualized by ultrasonography. Estradiol (E2) plasma concentration reached values of 5000 pg/ml. These findings indicate that pulsatile GnRH application can induce ovarian hyperstimulation.

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Authors and Affiliations

  1. Abteilung klinische Endokrinologie, Universitäts-Frauenklinik, Universität Freiburg, Hugstetter Strasse 55, D-7800, Freiburg i. Br., Federal Republic of Germany

    F. Geisthövel, F. Peters & M. Breckwoldt

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  1. F. Geisthövel
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  2. F. Peters
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  3. M. Breckwoldt
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Geisthövel, F., Peters, F. & Breckwoldt, M. Ovarian hyperstimulation due to long-term pulsatile intravenous GnRH treatment. Arch. Gynecol. 236, 255–259 (1985). https://doi.org/10.1007/BF02133944

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  • DOI: https://doi.org/10.1007/BF02133944

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