Abstract
The inner blood-retinal barrier is highly complex, dependent on a normally functioning retinal vascular endothelium and possibly adjacent perivascular cells. There are undoubtedly many different grades of barrier failure, and in the early stages an inbuilt compensatory mechanism may prevent significant fluid accumulation and delay associated structural and functional changes. In diabetes, early barrier failure may be a function of an increase in the rate of endothelial cell death and turnover, probably exaggerated by the early and widespread loss of the supporting cells and dilatation of the small blood vessels.
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References
Archer DB (1976) The nature of “new retinal vessels” Trans Ophthalmol Soc UK 96:210
Archer DB, Gardiner TA (1980) Experimental inner retinal ischaemia and the blood retinal barriers. In: Cunha-vaz JG (ed) The blood retinal barriers. Plenum Press, New York London, p 279
Archer DB, Gardiner TA (1981) Electron microscopic features of experimental choroidal neovascularization. Am J Ophthalmol 91:433
Buonassisi V, Venter JC (1976) Hormone and neurotransmitter receptors and established vascular endothelial cell line. Proc Natl Acad Sci USA 73:1612
Cunha-Vaz JG, Maurice DM (1967) The active transport of fluorescein by the retinal vessels and the retina. J Physiol 191:467
Cunha-Vaz JG, Shakib M, Ashton N (1966) Studies on the permeability of the blood retinal barrier. I. On the existence, development and site of a blood retinal barrier. Br J Ophthalmol 50:441
Cunha-Vaz JG, de Abreu JRF, Campos AJ, Figo GM (1975) Early breakdown of the blood retinal barrier in diabetes. Br J Ophthalmol 59:649
Engerman RL, Pfaffenbach D, Davis MD (1967) Cell turnover in capillaries. Lab Invest 17:738
Grayson MC, Laties AM (1971) Ocular localization of sodium fluorescein. Arch Ophthalmol 85:600
Ishibashi T, Tanaka K, Taniguchi Y (1980) Disruption of blood retinal barrier in experimental diabetic rats. An electron microscopic study. Exp Eye Research 30:401
Kuwabara T, Cogan DG (1980) Studies of retinal vascular patterns. I. Normal architecture. Arch Ophthalmol 64:904
Kuwabara T, Cogan DG (1963) Retinal vascular patterns. VI. Mural cells of the retinal capillaries. Arch Ophthalmol 69:492
Shepro D, D'Amore PA (1980) Endothelial cell metabolism. Advances in microcirculation, vol 9. Karger, Basel, p 161
Wallow IHL, Engerman RL (1977) Permeability and patency of retinal blood vessels in experimental diabetes. Invest Ophthalmol Vis Sci 16:447
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Archer, D.B., Gardiner, T.A. & Sharma, N.K. The inner blood-retinal barrier in diabetes. Graefe's Arch Clin Exp Ophthalmol 222, 186–188 (1985). https://doi.org/10.1007/BF02133671
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DOI: https://doi.org/10.1007/BF02133671