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Blood-Retinal Barrier Development and Potential for Regeneration in Blinding Eye Disease

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Tight Junctions

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Abstract

The blood-retinal barrier (BRB) creates the defined retinal environment necessary for neuronal signaling and vision. The well-developed tight junctions in the vascular endothelium and pigmented epithelium control transport to the neural parenchyma protecting the neural tissue from potential blood-borne toxicity. Retinal endothelial cells are intimately linked to astrocytes, mural cells including pericytes, neurons, and microglia that collectively promote differentiation of endothelium to the BRB. Loss of the BRB contributes to the pathophysiology of several retinal diseases including diabetic retinopathy, central retinal vein occlusion, retinopathy of prematurity, and age-related macular degeneration. This chapter will detail the current understanding of the development of the BRB focusing on the vascular component, describe the alterations to this barrier in blinding eye diseases, and explore how loss of the barrier contributes to loss of retinal function. Finally, this chapter will address the potential for regenerative therapies targeting restoration of the BRB and vascular function.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA

    Mónica Díaz-Coránguez & David A. Antonetti

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  1. Mónica Díaz-Coránguez
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  2. David A. Antonetti
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Correspondence to David A. Antonetti .

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  1. Department of Physiology, Biophysics, and Neuroscience, Center for Research and Advance Studies (Cinvestav), Mexico City, Mexico

    Lorenza González-Mariscal

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Díaz-Coránguez, M., Antonetti, D.A. (2022). Blood-Retinal Barrier Development and Potential for Regeneration in Blinding Eye Disease. In: González-Mariscal, L. (eds) Tight Junctions. Springer, Cham. https://doi.org/10.1007/978-3-030-97204-2_11

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