Abstract
In this work the possibility that a mutagenic factor acting in utero or in the perinatal period might lead to elevated mutagenic rates in bone-marrow cells after a considerable period of time was examined. An aromatic hydrocarbon, benzo(a)pyrene was used as the test substance. Benzo(a)pyrene treatments resulted in significantly higher sister-chromatid exchange (SCE)-frequencies in both fetal and neonatal groups in both sexes, even four months after exposure. In a second experiment we examined whether mutagenic exposure suffered in utero could make the individual more susceptible to mutagenic effects in adulthood. Preliminary results indicate that such a possibility could exist.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Hall, M., and Grover, P. L., in: Chemical Carcinogenesis and Mutagenesis, vol. I, p. 327. Eds C. S. Cooper and P. L. Grover. Springer Verlag, Heidelberg 1990.
Conner, M. K., and Cheng, M., Cancer Res.43 (1983) 965.
Morales-Ramirez, P., Rodríguez-Reyes, R., and Vallarino-Kelly, T., Mutat. Res.232 (1990) 77.
Schvartzman, J. B., Goyanes, V. J., Campos, A., Lage, A. M., Veiras, C., Silva, M. C., and Ramos, S., Chromosoma92 (1985) 7.
Stetka, D. G. Jr., Bleicher, W. T., and Brewen, J. G., Envir. Mutagen.7 (1985) 233.
Jones, I. M., Burkhart-Schultz, K., and Carrano, A. V., Mutat. Res.143 (1985) 245.
Tucker, J. D., Strout, C. L., Christensen, M. L., and Carrano, A. V., Envir. Mutagen.8 (1986) 345.
Gelboin, H. V., Physiol. Rev.60 (1980) 1107.
Schmid, W., Mutat. Res.31 (1975) 9.
Dean, B. J., and Danford, N., in: Mutagenicity Testing. A Practical Approach, p. 187. Eds S. Venitt and J. M. Parry. IRL Press, Oxford-Washington DC 1984.
Perry, P., and Wolff, S., Nature352 (1974) 156.
Heddle, J. A., Stuart, E., and Salamone, M. F., in: Handbook of Mutagenicity Test Procedures, p. 441. Eds B. J. Kilbey, M. Legator, W. Nichols and C. Ramel. Elsevier Science Publishers, Amsterdam 1984.
Csaba, G., Karabélyos, C., and Dalló, J., J. devl Physiol.19 (1993) 67.
Csaba, G., Biol. Rev.55 (1980) 47.
Csaba, G., Dobozy, O., and Szeberényi, S., Acta physiol. hung.70 (1987) 87.
Finnen, N. J., and Hassal, K. A., Biochem. Pharmac.29 (1980) 3133.
Haake-McMillan, J. M., and Safe, S. H., J. Biochem. Toxic.5 (1990) 203.
Lamartiniere, J. M., and Nicholas, J. N., Biochem. Pharmac.33 (1981) 4092.
Hosomi, J., Nemoto, N., and Kuroki, T., Cancer Res.43 (1983) 3643.
Harper, P. A., Golas, C. L., and Okey, A. B., Molec. Pharmac.40 (1991) 818.
Manchester, E., Gordon, S. K., Golas, C. L., Roberts, E. A., and Okey, A. B., Cancer Res.47 (1987) 4861.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Igaz, P., Tóth, S. & Csaba, G. Long-lasting persistence of elevated sister-chromatid exchange frequencies induced by perinatal benzo(a)pyrene treatment in rat bone-marrow cells. Experientia 51, 612–615 (1995). https://doi.org/10.1007/BF02128754
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02128754