Tolfenamic acid inhibits leukotriene synthesis in human granulocytes
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Higher concentrations of TA were needed to inhibit chemiluminescence than LTB4 formation (whereas indomethacin and timegadine reduced these two phenomena with similar potencies) suggesting a specific blockade of 5-lipoxygenase by TA. Oral TA decreased leukotriene production in PMNsex vivo. This may be related to the good anti-inflammatory and anti-migraine actions of TA, and partly explain its rare gastric and bronchoconstrictive adverse effects. However, the recommended single oral dose (100–400 mg) seems to be too low to decrease systemic LT-synthesis in all subjects.
KeywordsAdverse Effect Indomethacin Oral Dose Single Oral Dose LTB4
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