Advertisement

Agents and Actions

, Volume 26, Issue 1–2, pp 254–255 | Cite as

Tolfenamic acid inhibits leukotriene synthesis in human granulocytes

  • J. Alanko
  • E. Moilanen
  • J. Opas
  • H. Vapaatalo
General Inflammation

Conclusions

Higher concentrations of TA were needed to inhibit chemiluminescence than LTB4 formation (whereas indomethacin and timegadine reduced these two phenomena with similar potencies) suggesting a specific blockade of 5-lipoxygenase by TA. Oral TA decreased leukotriene production in PMNsex vivo. This may be related to the good anti-inflammatory and anti-migraine actions of TA, and partly explain its rare gastric and bronchoconstrictive adverse effects. However, the recommended single oral dose (100–400 mg) seems to be too low to decrease systemic LT-synthesis in all subjects.

Keywords

Adverse Effect Indomethacin Oral Dose Single Oral Dose LTB4 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    R. Fruchtmann, U. Krupka und B. Pelster,Hemmung des Lipoxygenase- und Cyclooxygenaseweges im Arachidonsäure-Metabolismus durch Etofenamat. Akt Rheumatol9, 165–168 (1984).Google Scholar
  2. [2]
    A. M. Boctor, M. Eickholt and T. A. Pugsley,Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro. Prostaglandins Leukotrienes Med23, 229–238 (1986).Google Scholar
  3. [3]
    E. Moilanen, J. Alanko, E. Seppälä and H. Vapaatalo,Effects of antirheumatic drugs on leukotriene B 4 and prostanoid synthesis in human polymorphonuclear leukocytes in vitro. Agents and Actions24, 387–394 (1988).PubMedGoogle Scholar
  4. [4]
    F. J. Zijlstra and J. E. Vincent,Determination of leukotrienes and prostaglandins in (14 C)-arachidonic acid labelled human lung tissue by high-performance liquid chromatography and radioimmunoassay. J Chromatogr311, 39–50 (1984).PubMedGoogle Scholar
  5. [5]
    E. Seppälä, O. Pora and T. Metsä-Ketelä,A modified method for extraction and purification of prostaglandins with resin XAD-2. Prostaglandins Leukotrienes Med14, 235–241 (1984).Google Scholar

Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • J. Alanko
    • 1
  • E. Moilanen
    • 1
  • J. Opas
    • 1
  • H. Vapaatalo
    • 1
  1. 1.Department of Biomedical SciencesUniversity of TampereTampereFinland

Personalised recommendations